Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [array]

ABSTRACT: A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [array]

PROVIDER: PRJNA800256 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease

Project description:A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease

| PRJNA801001 | ENA

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [array]

Project description:The intestinal epithelium is a single-cell layer comprising a constellation of specialized cell types that functionally interconnect host physiological systems with extrinsic microbial communities, metabolites, and dietary factors1. Active renewal of the intestinal epithelium relies on stem cells that reside in invaginations of the epithelium known as crypts. Inflammatory Bowel Disease (IBD) disrupts normal functions and/or proportions of cells in the intestinal epithelium, including stem cell programming during epithelial restitution. Genome-wide association studies have provided a powerful means to identify loci and genes contributing to IBD risk and functional annotation of candidate genes have unveiled cellular programs and molecular mechanisms involved in IBD etiology. Here we find that risk for a major form of IBD, Crohn’s disease (CD), is linked to a variant of the Fibroblast Growth Factor Receptor 1 Oncogene Partner (FGFR1OP) locus, which encodes a protein of the centrosome, the microtubule organizing center that generates microtubule structures involved in cell division, polarity, and motility. Deletion of Fgfr1op in mouse intestinal epithelium impaired stem cell division and intestinal crypt architecture causing crypt loss, inflammation and death. Transcriptional, biochemical and morphological analyses demonstrated that Fgfr1op coordinates the centrosome with the actin cytoskeleton and with specialized cell junctions known as desmosomes. We conclude that a genetically inherited centrosomal defect predisposes to CD by affecting renewal of the intestinal epithelium.

2024-06-17 | GSE194311 | GEO

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [RNA-Seq]

Project description:A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [RNA-Seq]

| PRJNA801005 | ENA

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [scRNA-Seq]

Project description:A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [scRNA-Seq]

| PRJNA800264 | ENA

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [RNA-Seq]

2024-06-17 | GSE195515 | GEO

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease [scRNA-Seq]

2024-06-17 | GSE194312 | GEO

A centrosomal defect of intestinal stem cells predisposes to Crohn’s Disease

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-06-17 | GSE195516 | GEO

Analysis of centrosomal protein

Project description:Shotgun proteomics and targeted analysis of centrosomal duplication factors controlled by SCF E3 ubiquitin ligases

2018-01-22 | PXD008272 | Pride

Neural tube closure defect

Project description:Neural tube closure defect

| PRJNA704672 | ENA

A BRCA1 coiled-coil domain variant disrupting PALB2 interaction predisposes to mammary tumors with a targetable defect in homologous recombination repair.

Project description:A BRCA1 coiled-coil domain variant disrupting PALB2 interaction predisposes to mammary tumors with a targetable defect in homologous recombination repair.

| PRJNA756277 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data