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RNA-seq datasets of Ro, GSK-591 and combination treatment in Z-138 cells

ABSTRACT: RNA-seq datasets of Ro, GSK-591 and combination treatment in Z-138 cells

PROVIDER: PRJNA800374 | ENA |

REPOSITORIES: ENA

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RNA-seq datasets of Ro, GSK-591 and combination treatment in Z-138 cells

Project description:Dual targeting of PRMT5 and MSI2 inhibited synergisticly B-cells proliferation. Thus, next-generation sequencing was performed to evaluate the effect of the inhibitors of PRMT5 and MSI2, GSK-591 and Ro, respectively, in the global transcriptome of the mantle cell lymphoma cell line, Z-138.

2022-08-17 | GSE194360 | GEO

Ro, GSK-591 and combination treatment in Z-138 cells

Project description:Ro, GSK-591 and combination treatment in Z-138 cells

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HyperTRIBE uncovers MSI2 RNA binding activity and the effect of Ro, GSK-591 and combination in Z-138 cells

Project description:Identifying MSI2 RNA-direct binding targets in B-cell lymphoma and evaluating how MSI2 binding activity can be affected by the inhibition of PRMT5 using GSK-591 and the MSI2 inhibitor, Ro and the combination of the two agents.

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HyperTRIBE uncovers MSI2 RNA binding activity and the effect of Ro, GSK-591 and combination in Z-138 cells

Project description:HyperTRIBE uncovers MSI2 RNA binding activity and the effect of Ro, GSK-591 and combination in Z-138 cells

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Ro, GSK-591 and combination treatment in Z-138 cells

Project description:This SuperSeries is composed of the SubSeries listed below.

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Gene expression in astrocytes upon sustained GSK-3 inhibition by small molecule

Project description:In order to identify molecular targets that mediates the stimulation of astrocyte's migration upon sustained specific inhibition of GSK-3, we have employed whole genome microarray expression profiling. Murine cortical-striatal astrocytes grown in primary culture were treated in vitro for 48 h with either 1 micromolar Ro3303544, or control medium (final equivalent concentration of DMSO), or washed-out for 48h in control medium after an initial 48h treatment with 1 micromolar Ro3303544. The three different conditions: Ctrl, Ro and wash-out (each in duplicate) were compared.

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