Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq of post mortem human central Amygdala samples in patients affected by opioid use disorder (OUD) vs. unaffected control samples

ABSTRACT: RNA-Seq of post mortem human central Amygdala samples in patients affected by opioid use disorder (OUD) vs. unaffected control samples

PROVIDER: PRJNA800378 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17736802_1.fastq.gz	Fastqsanger.gz
	SRR17736802_2.fastq.gz	Fastqsanger.gz
	SRR17736803_1.fastq.gz	Fastqsanger.gz
	SRR17736803_2.fastq.gz	Fastqsanger.gz
	SRR17736804_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 84

Similar Datasets

RNA-Seq of post mortem human central Amygdala samples in patients affected by opioid use disorder (OUD) vs. unaffected control samples

Project description:Differential expression analysis of human central Amygdala samples with a story of opioid use disorder (OUD) vs. unaffected control central Amygdala samples

2022-01-28 | GSE194368 | GEO

Transcriptomic profiling of mouse amygdala during opioid dependence and withdrawal by single-cell RNA sequencing

Project description:The development of substance use disorder (SUD) is a complex process involving multiple neurocircuitries and brain regions. The amygdala is a region that mediates the withdrawal effect as well as anxiety and depression-like behaviors. However, the transcriptional changes in each cell type during SUD is largely unknown. Here we performed single-cell RNA sequencing and classified all cell types in the mouse amygdala under opioid dependence and withdrawal states. Our data revealed distinct changes in key biological processes, such as immune response, inflammation, synaptic transmission, and mitochondrial respiration in different cell populations. Dramatic differences were unraveled in the transcriptional profiles between dependence and withdrawal states. This report is the first single-cell RNA sequencing dataset from the amygdala under opioid dependence and withdrawal conditions, providing unique insights in understanding brain alterations during SUD, especially at the molecular and cellular levels.

2023-11-08 | GSE207128 | GEO

Epigenome wide association study of post-mortem Alzheimer’s Disease samples

Project description:Samples from 72 AD patients and 62 age-matched cognitively normal controls were assayed using Illumina© Infinium MethylationEPIC BeadChip. We performed an epigenome-wide association study (EWAS) to evaluate the epigenetic differences using post-mortem superior temporal gyrus (STG) and inferior frontal gyrus (IFG) samples. We performed an epigenome-wide association study (EWAS) to evaluate the epigenetic differences using post-mortem superior temporal gyrus (STG) and inferior frontal gyrus (IFG) samples.

2020-10-20 | GSE156984 | GEO

Transcriptional responses of the human dorsal striatum in opioid use disorder implicates cell type-specifc programs

Project description:Gene expression profile at single cell level of striatal cells from the caudate nucleus and putamen in postmortem human brains of unaffected individuals or those with opioid use disorder.

2023-11-28 | GSE225158 | GEO

Gene Expression and Biomarker Utility in Post-Mortem Samples

Project description:Gene Expression and Biomarker Utility in Post-Mortem Samples

| PRJNA1074487 | ENA

Gene Expression and Biomarker Utility in Post-Mortem Samples

Project description:Gene Expression and Biomarker Utility in Post-Mortem Samples

| PRJNA1074488 | ENA

Epigenome-wide study of brain DNA methylation following acute opioid intoxication

Project description:Opioid abuse poses significant risk to individuals in the United States and epigenetic changes are a leading potential biomarker of opioid abuse. Current evidence, however, is mostly limited to candidate gene analysis in whole blood. Here, we provide Illumina HumanMethylationEPIC array data generated in dorsolateral prefrontal cortex tissue from 153 deceased invidiuals: 72 who died of acute opioid intoxication, 53 psychiatric controls, and 28 normal controls. Using these data, we conducted an epigenome-wide association study and identified one CpG site within a gene (NTN1) that may be related to opioid use. We also detected accelerated PhenoAge in opioid samples compared to control samples.

2021-04-01 | GSE164822 | GEO

Transcriptomic profiling of mouse amygdala during opioid dependence and withdrawal by single-cell RNA sequencing

Project description:Transcriptomic profiling of mouse amygdala during opioid dependence and withdrawal by single-cell RNA sequencing

| PRJNA853778 | ENA

Genome-wide methylation profiles of post-mortem tissue samples (human) 1

Project description:In this study, 60 post-mortem tissue samples comprising three tissue types (blood, brain, and heart) were collected from autopsies of 20 Koreans aged 18 to 78. 250 ng of genomic DNA (gDNA) was employed to generate DNA methylation profiles utilizing the Illumina Infinium MethylationEPIC BeadChip array (Illumina, San Diego, CA, USA) at Macrogen Inc. (Macrogen, Seoul, Korea).

2023-10-22 | GSE244993 | GEO

Genome-wide methylation profiles of post-mortem tissue samples (human) 3

Project description:In this study, 60 post-mortem tissue samples comprising four tissue types (dermis, epidermis, and muscle) were collected from autopsies of 20 Koreans aged 18 to 78. 250 ng of genomic DNA (gDNA) was employed to generate DNA methylation profiles utilizing the Illumina Infinium MethylationEPIC BeadChip array (Illumina, San Diego, CA, USA) at Macrogen Inc. (Macrogen, Seoul, Korea).

2023-10-22 | GSE244995 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data