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Long-distance association of topological boundaries through nuclear condensates

ABSTRACT: Long-distance association of topological boundaries through nuclear condensates

PROVIDER: PRJNA801249 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17786611.fastq.gz	Fastqsanger.gz
	SRR17786612.fastq.gz	Fastqsanger.gz
	SRR17786613.fastq.gz	Fastqsanger.gz
	SRR17786614.fastq.gz	Fastqsanger.gz
	SRR17786615.fastq.gz	Fastqsanger.gz

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Long-distance association of topological boundaries through nuclear condensates (Hi-C)

Project description:Chromatin is partitioned into distinct topological domains in an activity-dependent manner, with topological boundaries limiting the interaction between adjacent domains. Recent studies support the concept that several well-established nuclear compartments are assembled as ribonucleoprotein condensates. Here we ask whether the physical processes driving the assembly of the nuclear condensates play any role in three-dimensional chromatin architecture. We report that the insulation of approximately 20% of topological boundaries in human embryonic stem cells is substantially weakened following brief treatment with 1,6-hexanediol, a chemical known to disrupt several nuclear condensates. The disrupted boundaries are characterized by a high level of transcription, striking spatial clustering, and the augmented presence of transcription units widely expressed in diverse cell types. These topological boundary regions tend to be spatially associated, even inter-chromosomally, and segregate with nuclear speckles. These observations reveal a previously unappreciated mode of genome organization mediated by conserved boundary elements harboring widely-expressed transcription units and associated transcriptional condensates.

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Long-distance association of topological boundaries through nuclear condensates

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:Here we show that regions of the honeybee brain involved in visual processing and learning and memory show a genomic response to distance information. Using a method that separates effects of perceived distance from effects of actual distance flown, we found that individuals forced to shift from a short to a perceived long distance to reach a feeding site showed differences in gene expression in the optic lobes and mushroom bodies relative to individuals that continued to perceive flying a short distance.

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