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Early antiviral responses in monocytes and dendritic cells are associated with persistent humoral immunity to pertussis following Tdap-IPV vaccination

ABSTRACT: Early antiviral responses in monocytes and dendritic cells are associated with persistent humoral immunity to pertussis following Tdap-IPV vaccination

PROVIDER: PRJNA801507 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17801253_1.fastq.gz	Fastqsanger.gz
	SRR17801253_2.fastq.gz	Fastqsanger.gz
	SRR17801254_1.fastq.gz	Fastqsanger.gz
	SRR17801254_2.fastq.gz	Fastqsanger.gz
	SRR17801255_1.fastq.gz	Fastqsanger.gz

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Transcriptomic analysis of Tdap-IPV whole blood immune responses

Project description:Control of pertussis depends on primary vaccination of infants in combination with booster vaccination of children, adults, and recently also pregnant women. Tetanus-diptheria-acellular pertussis (Tdap) booster vaccines are frequently given in many countries and can be formulated with inactivated poliovirus (Tdap-IPV). Although Tdap-IPV provides clinical protection, both pertussis antibody levels and clinical protection decay shortly after vaccination. This highlights the need for a better understanding of the mechanisms of immunogenicity of aP-containing combination vaccines, which may explain the longevity of the antibody response to vaccination. In order to identify immune signatures that are induced by Tdap-IPV vaccination and which can be associated with humoral responses, we analyzed changes in gene expression.

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Early antiviral responses in monocytes and dendritic cells are associated with persistent humoral immunity to pertussis following Tdap-IPV vaccination

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