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Transcriptional modifications between Treg from healthy donors (HD) and Treg from patients suffering from warm autoimmune hemolytic anemia (wAIHA)

ABSTRACT: Transcriptional modifications between Treg from healthy donors (HD) and Treg from patients suffering from warm autoimmune hemolytic anemia (wAIHA)

PROVIDER: PRJNA802189 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17833845_1.fastq.gz	Fastqsanger.gz
	SRR17833845_2.fastq.gz	Fastqsanger.gz
	SRR17833846_1.fastq.gz	Fastqsanger.gz
	SRR17833846_2.fastq.gz	Fastqsanger.gz
	SRR17833847_1.fastq.gz	Fastqsanger.gz

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Transcriptional modifications between Treg from healthy donors (HD) and Treg from patients suffering from warm autoimmune hemolytic anemia (wAIHA)

Project description:We assessed Next Generation RNA Sequencing of circulating Treg from PBMC of HD or wAIHA patients and our results showed that Treg have an activated profile with sustained transcriptional and translational activity, as well as strong engagement of the TCR and TNF-a signaling pathway during wAIHA.

2024-02-14 | GSE195791 | GEO

Venous thromboembolic events during warm autoimmune hemolytic anemia.

Project description:Thrombotic manifestations are a hallmark of many auto-immune diseases (AID), specially of warm autoimmune hemolytic anemia (wAIHA), as 15 to 33% of adults with wAIHA experience venous thromboembolic events (VTE). However, beyond the presence of positive antiphospholipid antibodies and splenectomy, risk factors for developing a VTE during wAIHA have not been clearly identified. The aim of this retrospective study was to characterize VTEs during wAIHA and to identify risk factors for VTE. Forty-eight patients with wAIHA were included, among whom 26 (54%) had secondary wAIHA. Eleven (23%) patients presented at least one VTE, that occurred during an active phase of the disease for 10/11 patients (90%). The frequency of VTE was not different between primary and secondary AIHA (23.7 vs. 19.2%; p = 0.5). The Padua prediction score based on traditional risk factors was not different between patients with and without VTE. On multivariate analysis, total bilirubin ? 40 ?mol/L [odds ratio (OR) = 7.4; p = 0.02] and leucocyte count above 7x10(9)/L (OR = 15.7; p = 0.02) were significantly associated with a higher risk of thrombosis. Antiphospholipid antibodies were screened in 9 out the 11 patients who presented a VTE and were negative. Thus, the frequency of VTE is high (23%) during wAIHA and VTE preferentially occur within the first weeks of diagnosis. As no clinically relevant predictive factors of VTE could be identified, the systematic use of a prophylactic anticoagulation should be recommended in case of active hemolysis and its maintenance after hospital discharge should be considered. The benefit of a systematic screening for VTE and its procedure remain to be determined.

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Ominous comorbidities: Small ventricular septal defect and warm autoimmune hemolytic anemia.

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The effect of PHZ-induced hemolytic anemia on HSCs

Project description:The effect of PHZ-induced hemolytic anemia on HSCs

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The effect of PHZ-induced hemolytic anemia on HSCs [RNA-seq]

Project description:Hematopoietic stem cells (HSCs) are capable of regenerating the blood system, but the instructive cues that direct HSCs to regenerate particular lineages lost to the injury remain elusive. Here, we show that iron is increasingly taken up by HSCs during anemia and induces erythroid gene expression and regeneration in a Tet2-dependent manner. Lineage tracing of HSCs revealed that HSCs respond to hemolytic anemia by increasing erythroid output. The number of HSCs in the spleen, but not bone marrow, increased upon anemia and these HSCs exhibited enhanced proliferation, erythroid differentiation, iron uptake, and TET2 protein expression. Increased iron in HSCs promoted DNA demethylation and expression of erythroid genes. Suppressing iron uptake or TET2 expression impaired erythroid genes expression and erythroid differentiation of HSCs; iron supplementation, however, augmented these processes. These results establish that the physiological level of iron taken up by HSCs has an instructive role in promoting erythroid-biased differentiation of HSCs.

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The effect of PHZ-induced hemolytic anemia on HSCs [bisulfite-seq]

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Hemolytic bacteria

Project description:Hemolytic isolates from Arctic samples (Svalbard 2016-2017)

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Erythrocyte soluble proteome analysis in hemolytic anaemia patients

Project description:We investigated the RBCs of a hemolytic anemia patient using quantitative proteomics. We used stable isotope dimethyl labeling to accurately quantify the RBC proteins. As controls, 1) samples of four healthy subjects were taken to account for normal variation in healthy individuals, and 2) samples of two non-spherocytic hemolytic anemia patients were taken to account for differences in protein levels due to elevated reticulocyte content. We used a combination of strong cation exchange (SCX) chromatography with nanoLC-MS/MS, enabling quantification of RBC proteins.

2016-09-27 | PXD001837 | Pride

The effect of PHZ-induced hemolytic anemia on HSCs [RNA-seq]

Project description:The effect of PHZ-induced hemolytic anemia on HSCs [RNA-seq]

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