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Gene expression data from JUNB depleted exponentially growing U2OS-derived UTA6 cells

ABSTRACT: Gene expression data from JUNB depleted exponentially growing U2OS-derived UTA6 cells

PROVIDER: PRJNA802846 | ENA |

REPOSITORIES: ENA

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Gene expression data from JUNB depleted exponentially growing U2OS-derived UTA6 cells

Project description:To address the role of JUNB in cell proliferation, we investigated the consequences of JUNB depletion using U2OS human bone osteosarcoma cells. We used microarrays to detail the programme of JUNB dependent gene expression underlying cell proliferation and identified distinct classes of up and down-regulated genes during this process.

2022-09-29 | GSE195987 | GEO

RNA-seq on rRNA depleted libraries from exponentially growing Halobacterium salinarum NRC-1 strains Δura3 and Δhlx2

Project description:RNA-seq on rRNA depleted libraries from exponentially growing Halobacterium salinarum NRC-1 strains Δura3 and Δhlx2

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JUNB ChIP-seq

Project description:Genome-wide mapping of JUNB binding sites in U2OS cell line by ChIP-seq.

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Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells

Project description:NUDT5 was reported to generate ATP to support local chromatin remodeling and transcription of hormone-responsive genes. Our research has found that NUDT5 is also required for DNA damage repair by homologous recombination. To investigate how NUDT5 regulates HR, we depleted NUDT5 in U2OS cells by siRNA and compared the transcriptome profiling (RNA-seq) of NUDT5 depleted cells with control cells to investigate whether NUDT5 regulate HR by altering the expression of essential components of the HR machinery. The results suggest that NUDT5 does not regulate HR by altering the expression of essential components of the HR machinery. To investigate whether NUDT5 contributes to chromatin remodeling after DNA damage, we compared the chromatin accessibility profiling (ATAC-seq) in NUDT5 depleted U2OS cells and control cells, either before or after ionizing radiation. The results suggest that NUDT5 silencing blocked most DNA damage-induced changes in chromatin accessibility following radiation exposure and implies that NUDT5 may support the activity of remodeling ATPases during damage repair.

2023-02-14 | GSE196718 | GEO

Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [RNA-seq]

2023-02-14 | GSE196722 | GEO

Genome wide analsis of the chromatin accessibility and gene expression in control and NUDT5 depleted U2OS cells [ATAC-seq]

2023-02-14 | GSE196721 | GEO

Spontaneous cell competition in U2OS human osteosarcoma cells.

Project description:The study compares the transcriptional profiles of U2OS human osteosarcoma cells and those of two single-cell derived sub-lines carrying a stably integrated H2BmCherry (U2OS-R1) or H2B-YFP (U2OS-YFP) expression cassette. U2OS-R1 and U2OS-YFP cell spontaneously undergo apoptosis upon co-culture with the parental (Wt) U2OS cell population. Furthermore, YFP cells also undergo apoptosis upon co-culture with R1 cells. This behavior is similar to the \cell competition\ phenomenon described in the Drosophila imaginal disc and the mouse epiblast (for review, see , where fast-growing \fit\ cells induce apoptosis in slow-growing, less \fit\ neighbors. The mRNA expression profiles of Wt, R1 and YFP cells cultured alone or in pairwise combinations for 48h were analyzed after cell sorting by RNA microarray hybridization using Affymetrix Human Gene ST 1.0 chips.

2015-08-01 | E-MTAB-3204 | biostudies-arrayexpress

JUNB ChIP-seq

Project description:JUNB ChIP-seq

| PRJNA802851 | ENA

U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2

Project description:U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2 Keywords: other

2005-04-06 | GSE2292 | GEO

Glutamine deprivation in U2OS cells

Project description:To understand the effects of glutamine deprivation on cell physiology we performed global analysis of gene expression in response to glutamine deprivation. U2OS cells were subjected to glutamine deprivation for 24h followed by RNA extraction and microarray analysis. U2OS cells were plated overnight followed by treatment for 24h with glutamine-containing and glutamine-depleted media. Three biological replicates were assayed for each condition.

2014-07-31 | E-GEOD-59931 | biostudies-arrayexpress

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