Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pregestational Diabetes Alters Cardiac changes

ABSTRACT: Pregestational Diabetes Alters Cardiac changes

PROVIDER: PRJNA804008 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17907842_1.fastq.gz	Fastqsanger.gz
	SRR17907842_2.fastq.gz	Fastqsanger.gz
	SRR17907843_1.fastq.gz	Fastqsanger.gz
	SRR17907843_2.fastq.gz	Fastqsanger.gz
	SRR17907844_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Pregestational Diabetes Alters Cardiac changes

Project description:Objective: To evaluate the altered expression of genes due to hyperglycaemia during foetal development in heart. Methods: To understand the molecular defects in the two-days old neonatal rats, diabetic female rats were bred with healthy male rats and collected two days old hearts from neonates. Heart mRNA profiles of two-day-old neonatal rats were generated by RNA sequencing, in quadruplicate, using Illumina HiSeq. Results: Using an optimized data analysis workflow, we mapped about 27 million sequence reads per sample to the rat genome (build Rnor_6.0) and identified 25456 transcripts in the heart of the neonatal rats. Approximately 4% of the transcripts showed differential expression between the Control and PGDM (pregestational diabetes mellitus) heart, with a fold change ≥2 and p value <0.05. Conclusions: Transcriptomic profiling of the RNA-seq data revealed that several of the altered genes were associated with cardiac pathogenesis in neonatal heart during PGDM.

2022-07-01 | GSE196242 | GEO

Maternal diabetes alters transcriptional programs in the developing embryo.

Project description:Exposure to maternal diabetes during pregnancy alters transcriptional profiles in the developing embryo. The enrichment, within the set of de-regulated genes, of those encoding transcriptional regulatory molecules provides support for the hypothesis that maternal diabetes affects specific developmental programs. We compared E10.5 cntrol embryos to E10.5 embryos from diabetic pregnancies in the FVB mouse strain. Diabetes was induced in 7-9 week old female FVB mice by streptozotocin. Dams whose blood glucose levels exceeded 250 mg/dl were set up for mating. Embryos were dissected at E10.5 and total RNA was isolated. Equal amounts of RNA prepared from 3 individual embryos were pooled into one sample; each embryo was from a different pregnancy. Three pools were constructed for a total of nine embryos from diabetic pregnancies, and independently three pools for control embryos.

2012-09-25 | E-GEOD-41095 | biostudies-arrayexpress

Maternal diabetes alters transcriptional programs in the developing embryo.

2012-09-25 | GSE41095 | GEO

Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity

Project description:Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity

| PRJNA882101 | ENA

Time series of diabetes and exercise training induced expression changes in cardiac muscle of mice

Project description:We investigated the effects of diabetes, physical training, and their combination on the gene expression of cardiac muscle. Mice were divided to control (C), training (T), streptozotocin-induced diabetic (D), and diabetic training (DT) groups. Training groups performed 1, 3, or 5 weeks of endurance training on a motor-driven treadmill. Muscle samples from T and DT groups together with respective controls were collected 24 hours after the last training session. Gene expression of cardiac muscles were analyzed using Affymetrix Gene chip MG U74Av2 (Affymetrix , Inc., Santa Clara, CA). Keywords: time course

2006-09-01 | GSE4616 | GEO

Gestational diabetes mellitus alters placental structure, efficiency, and plasticity

Project description:Gestational diabetes mellitus alters placental structure, efficiency, and plasticity

| PRJNA603282 | ENA

Amyloid beta 42 alters cardiac metabolism and impairs cardiac function in obesity

Project description:There are epidemiological associations between obesity and type 2 diabetes, cardiovascular disease and Alzheimer’s disease. While some common aetiological mechanisms are known, the role of amyloid beta 42 (Ab42) in these diverse chronic diseases is obscure. Here we show that adipose tissue releases Ab42, which is increased from adipose tissue of obese mice and is associated with higher plasma Ab42. Increasing circulating Ab42 levels in mice had no effect on systemic glucose homeostasis but had obesity-like effects on the heart, including reduced cardiac glucose clearance and impaired cardiac function. These effects on cardiac function were not observed when circulating Ab40 levels were increased. Administration of an Ab neutralising antibody prevented obesity-induced cardiac dysfunction and hypertrophy. Furthermore, Ab neutralising antibody administration in established obesity prevented further deterioration of cardiac function. Multi-contrast transcriptomic analyses revealed that Ab42 impacted pathways of mitochondrial metabolism and exposure of cardiomyocytes to Ab42 inhibited mitochondrial function. These data reveal a role for systemic Ab42 in the development of cardiac disease in obesity and suggest that therapeutics designed for Alzheimer’s disease could be effective in combating obesity-induced heart failure.

2022-09-22 | GSE213708 | GEO

Mapping the cellular and molecular landscape of cardiac non-myocytes in murine type-2 diabetes

Project description:Here we define key single-cell transcriptional alterations within cardiac non-myocytes, from ventricles of spontaneously type-2 diabetic (db/db) and control (db/h) mouse hearts ([B6.BKS(D)-Lepr<db>/J], stock #000697). The cell preparation sequenced consisted of metabolically active, live and nucleated non-myocyte cells, which were depleted of endothelial cells. The objective of this experiment was to develop a framework for understanding the dynamics of cardiac cell networks in murine type-2 diabetes, as a resource for future mechanistic studies.

2022-11-29 | E-MTAB-11940 | biostudies-arrayexpress

Cardiac miRNA expression changes induced by prediabetes

Project description:Cardiac miRNA expression changes induced by prediabetes

| PRJEB33812 | ENA

Transthyretin alters cardiac fibroblast structure, function and inflammatory gene expression.

Project description:Transthyretin alters cardiac fibroblast structure, function and inflammatory gene expression.

| PRJNA734300 | ENA