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The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries [scRNA-seq]

ABSTRACT: The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries [scRNA-seq]

PROVIDER: PRJNA804433 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17936867.fastq.gz	Fastqsanger.gz
	SRR17936868_1.fastq.gz	Fastqsanger.gz
	SRR17936868_2.fastq.gz	Fastqsanger.gz
	SRR17936869.fastq.gz	Fastqsanger.gz
	SRR17936870.fastq.gz	Fastqsanger.gz

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The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries [scRNA-seq]

Project description:Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T cells (Tregs) crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Tregs that promote tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver. Tissue damage elicited the emigration of RORγ+ Tregs from the gut to compromised tissues, wherein they regulated the dynamics and tenor of early inflammation and helped balance the proliferation versus differentiation of local stem cells. Reining in IL-17A-producing T cells was a major mechanism underlying these rheostatic functions. Our findings highlight the importance of gut-trained Treg emissaries in controlling the response to sterile injury of non-mucosal tissues.

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The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Project description:The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

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The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries [bulk RNA-seq]

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The gut microbiota promotes distal tissue regeneration via RORγ<sup>+</sup> regulatory T cell emissaries.

Project description:Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T (Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver. Inflammatory meditators elicited by tissue damage combined with MHC-class-II-dependent T cell activation to drive the accumulation of gut-derived RORγ+ Treg cells in injured muscle, wherein they regulated the dynamics and tenor of early inflammation and helped balance the proliferation vs. differentiation of local stem cells. Reining in IL-17A-producing T cells was a major mechanism underlying the rheostatic functions of RORγ+ Treg cells in compromised tissues. Our findings highlight the importance of gut-trained Treg cell emissaries in controlling the response to sterile injury of non-mucosal tissues.

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The gut microbiota promotes distal tissue regeneration via RORγ+ regulatory T cell emissaries

Project description:This SuperSeries is composed of the SubSeries listed below.

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