Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The lncRNA RUS shapes gene expression program towards neurogenesis [ChIRP-seq]

ABSTRACT: The lncRNA RUS shapes gene expression program towards neurogenesis [ChIRP-seq]

PROVIDER: PRJNA805253 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17976052_1.fastq.gz	Fastqsanger.gz
	SRR17976052_2.fastq.gz	Fastqsanger.gz
	SRR17976053_1.fastq.gz	Fastqsanger.gz
	SRR17976053_2.fastq.gz	Fastqsanger.gz
	SRR17976054_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 15

Similar Datasets

The lncRNA RUS shapes gene expression program towards neurogenesis [ChIRP-seq]

Project description:The evolution of brain complexity correlates with an increased expression of long, non-coding (lnc) RNAs in neuronal tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during neurogenesis. We present a first functional characterization of the lncRNA LINC01322, which we term RUS for 'RNA upstream of Slitrk3'. The RUS gene is well conserved in mammals by sequence and synteny next to the neurodevelopmental gene Slitrk3. RUS is exclusively expressed in neural cells and its expression increases along with neuronal markers during neuronal differentiation of mouse embryonic cortical neural stem cells. Depletion of RUS locks neuronal precursors in an intermediate state towards neuronal differentiation, with arrested cell cycle and increased apoptosis. RUS associates with chromatin in the vicinity of genes involved in neurogenesis, most of which change their expression upon RUS depletion. The identification of a range of epigenetic regulators as specific RUS interactors suggests that the lncRNA may mediate gene activation and repression in a highly context-dependent manner.

2022-05-24 | GSE196527 | GEO

LncRNA RUS shapes the gene expression program towards neurogenesis

Project description:The evolution of brain complexity correlates with an increased expression of long, non-coding (lnc) RNAs in neuronal tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during neurogenesis. We present a first functional characterization of the lncRNA LINC01322, which we term RUS for ‘RNA upstream of Slitrk3’. The RUS gene is well conserved in mammals by sequence and synteny next to the neurodevelopmental gene Slitrk3. RUS is exclusively expressed in neural cells and its expression increases along with neuronal markers during neuronal differentiation of mouse embryonic cortical neural stem cells. Depletion of RUS locks neuronal precursors in an intermediate state towards neuronal differentiation, with arrested cell cycle and increased apoptosis. RUS associates with chromatin in the vicinity of genes involved in neurogenesis, most of which change their expression upon RUS depletion. The identification of a range of epigenetic regulators as specific RUS interactors suggests that the lncRNA may mediate gene activation and repression in a highly context-dependent manner.

2022-06-21 | PXD031664 | Pride

The lncRNA RUS shapes gene expression program towards neurogenesis [RNA-Seq ]

Project description:The evolution of brain complexity correlates with an increased expression of long, non-coding (lnc) RNAs in neuronal tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during neurogenesis. We present a first functional characterization of the lncRNA LINC01322, which we term RUS for ‘RNA upstream of Slitrk3’. The RUS gene is well conserved in mammals by sequence and synteny next to the neurodevelopmental gene Slitrk3. RUS is exclusively expressed in neural cells and its expression increases along with neuronal markers during neuronal differentiation of mouse embryonic cortical neural stem cells. Depletion of RUS locks neuronal precursors in an intermediate state towards neuronal differentiation, with arrested cell cycle and increased apoptosis. RUS associates with chromatin in the vicinity of genes involved in neurogenesis, most of which change their expression upon RUS depletion. The identification of a range of epigenetic regulators as specific RUS interactors suggests that the lncRNA may mediate gene activation and repression in a highly context-dependent manner.

2022-05-24 | GSE196487 | GEO

The lncRNA RUS shapes gene expression program towards neurogenesis

Project description:The lncRNA RUS shapes gene expression program towards neurogenesis

| PRJNA805250 | ENA

The lncRNA RUS shapes gene expression program towards neurogenesis [RNA-Seq ]

Project description:The lncRNA RUS shapes gene expression program towards neurogenesis [RNA-Seq ]

| PRJNA805191 | ENA

LncRNA <i>RUS</i> shapes the gene expression program towards neurogenesis.

Project description:The evolution of brain complexity correlates with an increased expression of long, noncoding (lnc) RNAs in neural tissues. Although prominent examples illustrate the potential of lncRNAs to scaffold and target epigenetic regulators to chromatin loci, only few cases have been described to function during brain development. We present a first functional characterization of the lncRNA LINC01322, which we term RUS for "RNA upstream of Slitrk3." The RUS gene is well conserved in mammals by sequence and synteny next to the neurodevelopmental gene Slitrk3. RUS is exclusively expressed in neural cells and its expression increases during neuronal differentiation of mouse embryonic cortical neural stem cells. Depletion of RUS locks neuronal precursors in an intermediate state towards neuronal differentiation resulting in arrested cell cycle and increased apoptosis. RUS associates with chromatin in the vicinity of genes involved in neurogenesis, most of which change their expression upon RUS depletion. The identification of a range of epigenetic regulators as specific RUS interactors suggests that the lncRNA may mediate gene activation and repression in a highly context-dependent manner.

| S-EPMC9187872 | biostudies-literature

The lncRNA RUS shapes gene expression program towards neurogenesis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-05-24 | GSE196528 | GEO

Porites rus

Project description:Porites rus overview

| PRJNA1109510 | ENA

KCNQOT1 ChIRP seq and perturbation epigentic profiles [ChIRP]

Project description:KCNQOT1 ChIRP seq and perturbation epigentic profiles [ChIRP]

| PRJNA858014 | ENA

Brachionus manjavacas isolate:RUS

Project description:Brachionus manjavacas isolate:RUS Raw sequence reads