Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [HSCP]

ABSTRACT: Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [HSCP]

PROVIDER: PRJNA805356 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR17982188_1.fastq.gz	Fastqsanger.gz
	SRR17982188_2.fastq.gz	Fastqsanger.gz
	SRR17982189_1.fastq.gz	Fastqsanger.gz
	SRR17982189_2.fastq.gz	Fastqsanger.gz
	SRR17982190_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Project description:Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

| PRJNA805354 | ENA

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [macrophages]

Project description:Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [macrophages]

| PRJNA805357 | ENA

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [HSCP]

Project description:Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly formed stem cells. We observed intimate and specific interactions between macrophages and blood stem cells in zebrafish embryos. Stressed stem cells were marked by surface Calreticulin, which stimulates macrophage interaction as an “eat me” signal. Macrophage-stem cell interactions either lead to removal of cytoplasmic material and stem cell proliferation or resulted in complete stem cell engulfment. Using cellular barcoding, we found that calreticulin knock-down or embryonic macrophage depletion substantially reduced the number of stem cell clones into adulthood. Our work supports a model in which embryonic macrophages determine hematopoietic clonality by monitoring stem cell quality.

2022-10-19 | GSE196552 | GEO

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality [macrophages]

2022-10-19 | GSE196551 | GEO

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Project description:There are no described quality assurance mechanisms for newly formed stem cells. We observed intimate interactions between macrophages and blood stem cells in zebrafish embryos. Stressed stem cells were marked by surface Calreticulin, which stimulates macrophage interaction as an eat me signal. Macrophage-stem cell interactions either lead to removal of cytoplasmic material and stem cell proliferation or resulted in complete stem cell engulfment. Calreticulin knock down or embryonic macrophage depletion reduced the number of stem cell clones into adulthood. Our work supports a model in which embryonic macrophages determine hematopoietic clonality by monitoring stem cell quality.

2022-02-04 | MSV000088780 | MassIVE

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality.

Project description:Tissue-specific stem cells persist for a lifetime and can differentiate to maintain homeostasis or transform to initiate cancer. Despite their importance, there are no described quality assurance mechanisms for newly formed stem cells. We observed intimate and specific interactions between macrophages and nascent blood stem cells in zebrafish embryos. Macrophage interactions frequently led to either removal of cytoplasmic material and stem cell division or complete engulfment and stem cell death. Stressed stem cells were marked by surface Calreticulin, which stimulated macrophage interactions. Using cellular barcoding, we found that Calreticulin knock-down or embryonic macrophage depletion reduced the number of stem cell clones that established adult hematopoiesis. Our work supports a model in which embryonic macrophages determine hematopoietic clonality by monitoring stem cell quality.

| S-EPMC9524573 | biostudies-literature

Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-10-19 | GSE196553 | GEO

Habitat Quality Determines Fitness

Project description:Microbiom analysis of: "Habitat Quality Determines Dispersal Decisions and Fitness in a Beetle – Fungus Mutualism."

| PRJEB44223 | ENA

A radical switch in clonality reveals the formation of a stem cell niche in the epiphyseal growth plate

Project description:A radical switch in clonality reveals the formation of a stem cell niche in the epiphyseal growth plate

2019-01-03 | GSE113982 | GEO

IFN gamma signaling in cytotoxic T cells restricts antitumor responses by inhibiting the maintenance and clonality of intra-tumoral stem-like T cells

Project description:IFN gamma signaling in cytotoxic T cells restricts antitumor responses by inhibiting the maintenance and clonality of intra-tumoral stem-like T cells

2022-12-16 | GSE221118 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data