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Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia

ABSTRACT: Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia

PROVIDER: PRJNA805507 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR17982700_1.fastq.gz	Fastqsanger.gz
	SRR17982700_2.fastq.gz	Fastqsanger.gz
	SRR17982701_1.fastq.gz	Fastqsanger.gz
	SRR17982701_2.fastq.gz	Fastqsanger.gz
	SRR17982702_1.fastq.gz	Fastqsanger.gz

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Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [SM_CHOW_HFSC]

Project description:Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [SM_CHOW_HFSC]

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Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_CHOW]

Project description:Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_CHOW]

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Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_HFSC]

Project description:Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_HFSC]

| PRJNA805508 | ENA

Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-10-01 | GSE196566 | GEO

Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [SM_CHOW_HFSC]

Project description:We report transcriptomic changes in skeletal muscle of systemic miR-181a2b2 KO mice in response to chow and HFSC diet feeding and hindlimb ischemia

2023-10-01 | GSE196565 | GEO

Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_CHOW]

Project description:We report transcriptomic changes in bone marrow cells of systemic miR-181a2b2 KO mice in response after chow diet feeding and hindlimb ischemia

2023-10-01 | GSE196562 | GEO

Bone marrow MiR-181a/b-CXCR4 signaling axis impairs hematopoiesis, monocytosis, and angiogenesis in diabetic critical limb ischemia [BM_HFSC]

Project description:We report transcriptomic changes in bone marrow cells of systemic miR-181a2b2 KO mice in response after HFSC diet feeding and hindlimb ischemia

2023-10-01 | GSE196561 | GEO

Identifying downstream targets of microRNA-181a in chondrosarcoma cells.

Project description:microRNAs are small (22-24 nucleotide), non-coding RNA transcripts that play a role in RNA silencing and post transcriptional regulation of gene expression. They have been implicated to have profound roles in many cancers. The role of microRNAs in chondrosarcoma progression is not well understood. Our lab has identified miR-181a to be up-regulated in chondrosarcoma. miR-181a modulates CXCR4 signaling by targeting RGS-16, leading to increased levels of VEGF and MMP-1, major factors in tumor invasion. In an effort to identify other targets of miR-181a apart from RGS-16, we carried out a gene array to compare gene expression between untreated/control CS-1(chondrosarcoma cell line) cells and CS-1 cells transduced with a lenti virus expression construct with anti-miR-181a sequence.

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A miRNA/CXCR4 signaling axis impairs monopoiesis and angiogenesis in diabetic critical limb ischemia.

Project description:Patients with peripheral artery disease (PAD) and diabetes have the highest risk of critical limb ischemia (CLI) and amputation, yet the underlying mechanisms remain incompletely understood. MicroRNA (miRNA) sequencing of plasma from diabetic patients with or without CLI was compared to diabetic mice with acute or subacute limb ischemia to identify conserved miRNAs. miRNA-KO mice on high-fat diet were generated to explore the impact on CLI. Comparison of dysregulated miRNAs from diabetic individuals with PAD and diabetic mice with limb ischemia revealed conserved miR-181 family members. High-fat-fed, diabetic Mir181a2b2-KO mice had impaired revascularization in limbs due to abrogation of circulating Ly6Chi monocytes, with reduced accumulation in ischemic skeletal muscles. M2-like KO macrophages under diabetic conditions failed to produce proangiogenic cytokines. Single-cell transcriptomics of the bone marrow niche revealed that the reduced monocytosis in diabetic KO mice was a result of impaired hematopoiesis, with increased CXCR4 signaling in bone marrow Lineage-Sca1+Kit+ (LSK) cells. Exogenous Ly6Chi monocytes from nondiabetic KO mice rescued the impaired revascularization in ischemic limbs of diabetic KO mice. Increased Cxcr4 expression was mediated by the miR-181 target, Plac8. Taken together, our results show that MiR-181a/b is a putative mediator of diabetic CLI and contributes to changes in hematopoiesis, monocytosis, and macrophage polarization.

| S-EPMC10132154 | biostudies-literature

CXCR4/miR-1910-5p/MMRN2 Axis is Involved in Corneal Neovascularization by Affecting Vascular Permeability

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2023-04-26 | GSE226185 | GEO

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