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Modeling exercise using optogenetically contractible Drosophila larvae

ABSTRACT: Modeling exercise using optogenetically contractible Drosophila larvae

PROVIDER: PRJNA807593 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18050282.fastq.gz	Fastqsanger.gz
	SRR18050283.fastq.gz	Fastqsanger.gz
	SRR18050284.fastq.gz	Fastqsanger.gz
	SRR18050285.fastq.gz	Fastqsanger.gz
	SRR18050286.fastq.gz	Fastqsanger.gz

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Modeling exercise using optogenetically contractible Drosophila larvae

Project description:The pathophysiological effects of a number of metabolic and age-related disorders can be prevented to some extent by exercise and increased physical activity. However, the molecular mechanisms that contribute to the beneficial effects of muscle activity remain poorly explored. Availability of a fast, inexpensive, and genetically tractable model for muscle activity and exercise will allow rapid identification and characterization of the molecular mechanisms that mediate the beneficial effects of muscle activity. Here, we report the development and characterization of an optogenetically-inducible muscle contraction (OMC) model in Drosophila larvae that we used to model acute exercise-like physiological responses. To characterize muscle-specific transcriptional responses to acute exercise, we performed bulk mRNA-sequencing, revealing striking similarities between acute exercise-induced genes in flies and those previously identified in humans. Our larval muscle contraction model opens a path for rapid identification and characterization of exercise-induced factors.

2022-09-15 | GSE196850 | GEO

Modeling exercise using optogenetically contractible Drosophila larvae.

Project description:The pathophysiological effects of a number of metabolic and age-related disorders can be prevented to some extent by exercise and increased physical activity. However, the molecular mechanisms that contribute to the beneficial effects of muscle activity remain poorly explored. Availability of a fast, inexpensive, and genetically tractable model system for muscle activity and exercise will allow the rapid identification and characterization of molecular mechanisms that mediate the beneficial effects of exercise. Here, we report the development and characterization of an optogenetically-inducible muscle contraction (OMC) model in Drosophila larvae that we used to study acute exercise-like physiological responses. To characterize muscle-specific transcriptional responses to acute exercise, we performed bulk mRNA-sequencing, revealing striking similarities between acute exercise-induced genes in flies and those previously identified in humans. Our larval muscle contraction model opens a path for rapid identification and characterization of exercise-induced factors.

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