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Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [snATAC-seq]

ABSTRACT: Durable Alterations of Hematopoiesis and Chromatin post-COVID-19 [snATAC-seq]

PROVIDER: PRJNA808247 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18070458.fastq.gz	Fastqsanger.gz
	SRR18070458_1.fastq.gz	Fastqsanger.gz
	SRR18070458_2.fastq.gz	Fastqsanger.gz
	SRR18070459.fastq.gz	Fastqsanger.gz
	SRR18070459_1.fastq.gz	Fastqsanger.gz

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Project description:Acute SARS-CoV-2 infection is often highly inflammatory and protracted. Recent advances have established that inflammation can trigger innate immune memory and a persistent influence on hematopoietic development, through epigenetic mechanisms. However, these phenotypes and their molecular and cellular features are poorly described in humans. Here we reveal epigenomic alterations in innate immune and hematopoietic stem and progenitor cells (HSPC) post-COVID-19, with distinct molecular programs across disease severities. Enabled by novel approaches to study hematopoiesis from peripheral blood, we find persisting HSPC epigenetic programs conveyed, for months to a year, to short-lived progeny monocytes. These epigenetic changes are associated with increased myeloid cell differentiation and inflammatory and antiviral programs. We provide insights into post-infectious HSPC and innate immune cell epigenetic alterations that are broadly relevant.

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