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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC ex vivo]

ABSTRACT: Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC ex vivo]

PROVIDER: PRJNA808411 | ENA |

REPOSITORIES: ENA

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC in vitro]

Project description:Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC in vitro]

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scRNA ex vivo]

Project description:Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scRNA ex vivo]

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC ex vivo]

Project description:We report profiling of single cell chromatin accessbility and gene expression of human NK cells from CMV-seropositive and -negative healthy blood donors ex vivo, as well as chromatin remodeling after in vitro stimulation via NKG2C and/or IL-12+IL-18.

2022-09-05 | GSE197008 | GEO

Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scATAC in vitro]

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory [scRNA ex vivo]

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Clonal expansion and epigenetic inheritance shape long-lasting NK cell memory

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-05 | GSE197037 | GEO

Germ Granules Govern Small RNA Inheritance

Project description:In C. elegans nematodes, components of liquid-like germ granules were shown to be required for transgenerational small RNA inheritance. Surprisingly, we show here that mutants with defective germ granules can nevertheless inherit potent small RNA-based silencing responses, but some of the mutants lose this ability after many generations of homozygosity. Animals mutated in pptr-1, which is required for stabilization of P granules in the early embryo, display extraordinarily strong heritable RNAi responses, lasting for tens of generations. Intriguingly, the RNAi capacity of descendants derived from mutants defective in the core germ granules proteins MEG-3 and MEG-4 is determined by the genotype of the ancestors, and changes transgenerationally. Further, whether the meg-3/4 mutant alleles were present in the paternal or maternal lineages lead to different transgenerational consequences. Small RNA inheritance, rather than maternal contribution of the germ granules themselves, mediates the transgenerational defects in RNAi of meg-3/4 mutants and their progeny. Accordingly, germ granule defects lead to heritable genome-wide mis-expression of endogenous small RNAs. Upon disruption of germ granules, hrde-1 mutants can inherit RNAi although HRDE-1 was previously thought to be absolutely required for RNAi inheritance. We propose that germ granules sort and shape the RNA pool, and that small RNA inheritance maintains this activity for multiple generations.

2019-07-31 | GSE128112 | GEO

Clonal expansion and epigenetic inheritance of long-lasting NK cell memory.

Project description:Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer (NK) cell memory to human cytomegalovirus (HCMV) infection. Leveraging single-cell multiomic maps of ex vivo NK cells and somatic mitochondrial DNA mutations as endogenous barcodes, we reveal substantial clonal expansion of adaptive NK cells in HCMV+ individuals. NK cell clonotypes were characterized by a convergent inflammatory memory signature enriched for AP1 motifs superimposed on a private set of clone-specific accessible chromatin regions. NK cell clones were stably maintained in specific epigenetic states over time, revealing that clonal inheritance of chromatin accessibility shapes the epigenetic memory repertoire. Together, we identify clonal expansion and persistence within the human innate immune system, suggesting that these mechanisms have evolved independent of antigen-receptor diversification.

| S-EPMC9663309 | biostudies-literature

scATAC-seq of mouse Plasmodium-specific CD4+ T cells

Project description:Plasmodium-specific CD4+ T cells from mice infected with Plasmodium chabaudi chabaudi AS parasites were recovered at Days 0, 4, 7, and 32 to undergo processing and to generate scATAC-seq dataset. At Day 7, CXCR5+ and CXCR6+ cells were recovered separately. At Day 32, mice were administered with either saline or artesunate (intermittent artesunate therapy - IAT). scATAC-seq dataset was analysed to investigate epigenomic landscapes of CD4+ T cells from effector to memory states.

2020-10-14 | E-MTAB-9402 | biostudies-arrayexpress

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