Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [miRNA-seq]

ABSTRACT: Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [miRNA-seq]

PROVIDER: PRJNA809337 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18099074.fastq.gz	Fastqsanger.gz
	SRR18099075.fastq.gz	Fastqsanger.gz
	SRR18099076.fastq.gz	Fastqsanger.gz
	SRR18099077.fastq.gz	Fastqsanger.gz
	SRR18099078.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy

Project description:Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy

| PRJNA809381 | ENA

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [array]

Project description:Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [array]

| PRJNA809383 | ENA

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [array]

Project description:Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiomyopath that caused by mutations in genes encoding proteins of the cardiac sarcomere. Although multiple efforts have been made to understand the pathogenesis of HCM, the mechanisms of how long noncoding RNA (lncRNA)-associated competing endogenous RNA (ceRNA) network result in HCM still unkown. Herein, we acquired the different expression profiles of lncRNAs (DElncRNAs) and messenger RNAs (mRNA, DEGs) by using microarray, microRNAs (DEmiRNAs) by sequencing in plasma of HCM patients and healthy controls. LncRNA-miRNA pairs were predicted using miRcode and starBase, and crossed with DEmiRNAs. MiRNA-mRNA pairs were retrieved from miRanda and TargetScan, and crossed with DEGs. Combined these pairs, the ceRNA network was constructed and hub nodes were then analyzed to reconstruct subnetwork. Gene Ontology and KEGG pathways were used to analyse the mRNAs in the ceRNA. Total 520 DElncRNAs, 33 DEmiRNAs, and 371 DEGs were identified. By coexpression analysis, 682 lncRNA-mRNA pairs were identiﬁed with a coefﬁcient ≥ 0.9 and p < 0.05. The ceRNA network with 8 lncRNAs, 3 miRNAs and 22 mRNAs was constructed visualized by Cytoscape. LncRNA RP11-66N24.4 and LINC00310 are among the top 10% nodes and the associated ceRNA subnetwork may be the center of the whole ceRNA network. Furthermore, the qRT-PCR results showed that LINC00310 was signifcantly decreased in HCM patients. For LINC00310, GO analysis revealed that the biological processes was enriched in cardiovascular system development, sprouting angiogenesis, circulatory system development and so on, and Pathway analysis was mainly enriched in cGMP-PKG signaling pathway. Our study reveals the novel lncRNA-related ceRNA network in HCM and the identified lncRNA LINC00310 may be roles in the pathogenesis mechanisms of HCM, which could provide further insight into the pathogenesis of HCM.

2022-09-28 | GSE197218 | GEO

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy [miRNA-seq]

2022-09-28 | GSE197191 | GEO

Long noncoding RNA related-competing endogenous RNAs in retinal pigment epithelial cells induced by clusterin

Project description:long noncoding RNAs (lncRNAs) play crucial roles in regulating gene expression by acting as competing endogenous RNAs (ceRNAs).

2016-09-22 | GSE87167 | GEO

Reconstruction and Analysis of a Long Noncoding RNA-Associated Competing Endogenous RNA Network in Hypertrophic Cardiomypathy

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-09-28 | GSE197219 | GEO

Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients

Project description:1. Evaluate the diagnostic value of long noncoding RNA (CCAT1) expression by RT-PCR in peripheral blood in colorectal cancer patients versus normal healthy control personal. 2. Evaluate the clinical utility of detecting long noncoding RNA (CCAT1) expression in diagnosis of colorectal cancer patients & its relation to tumor staging. 3. Evaluate the clinical utility of detecting long noncoding RNA (CCAT1) expression in precancerous colorectal diseases. 4. Compare long noncoding RNA (CCAT1) expression with traditional marker; carcinoembryonic antigen (CEA) and Carbohydrate antigen 19-9 (CA19-9) in diagnosis of colorectal cancer.

| 2330122 | ecrin-mdr-crc

Transcriptomic analysis and competing endogenous RNA network in the human endometrium between proliferative and mid-secretory phases

Project description:To identify differentially expressed transcripts (long-noncoding RNAs [lncRNAs], microRNAs [miRNAs], and mRNAs) and competing endogenous RNA (ceRNA) networks closely connected with endometrial receptivity, we analyzed gene expression profiles between the proliferative and mid-secretory endometria in fertile women.

2021-02-24 | GSE167325 | GEO

Circulating long noncoding RNAs associated with hypertrophic cardiomyopathy

Project description:Circulating long noncoding RNAs associated with hypertrophic cardiomyopathy

| PRJNA601680 | ENA

Long Noncoding Competing Endogenous RNA Networks in Pancreatic Cancer.

Project description:Pancreatic cancer (PC) is a highly malignant disease characterized by insidious onset, rapid progress, and poor therapeutic effects. The molecular mechanisms associated with PC initiation and progression are largely insufficient, hampering the exploitation of novel diagnostic biomarkers and development of efficient therapeutic strategies. Emerging evidence recently reveals that noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), extensively participate in PC pathogenesis. Specifically, lncRNAs can function as competing endogenous RNAs (ceRNAs), competitively sequestering miRNAs, therefore modulating the expression levels of their downstream target genes. Such complex lncRNA/miRNA/mRNA networks, namely, ceRNA networks, play crucial roles in the biological processes of PC by regulating cell growth and survival, epithelial-mesenchymal transition and metastasis, cancer stem cell maintenance, metabolism, autophagy, chemoresistance, and angiogenesis. In this review, the emerging knowledge on the lncRNA-associated ceRNA networks involved in PC initiation and progression will be summarized, and the potentials of the competitive crosstalk as diagnostic, prognostic, and therapeutic targets will be comprehensively discussed.

| S-EPMC8573238 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data