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Expression data from differentiated murine 3T3-L1 pre-adipocytes treated with alpha-linolenic acid (ALA) and delta-6-desaturase (D6D) inhibitor

ABSTRACT: Expression data from differentiated murine 3T3-L1 pre-adipocytes treated with alpha-linolenic acid (ALA) and delta-6-desaturase (D6D) inhibitor

PROVIDER: PRJNA809392 | ENA |

REPOSITORIES: ENA

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Expression data from differentiated murine 3T3-L1 pre-adipocytes treated with alpha-linolenic acid (ALA) and delta-6-desaturase (D6D) inhibitor

Project description:The goal of this study was to investigate the individual and combined effects of alpha-linolenic acid (the essential omega-3 fatty acid) and an inhibitor of the delta-6 desaturse (SC-26196) during adipocye differentiation.

2022-04-21 | GSE197225 | GEO

Growth Hormone (GH) Treatment of 3T3-F442A Adipocytes

Project description:Expression profiling of 3T3-F442A adipocytes treated with growth hormone (GH, 500 nM) or vehicle (DMEM + 1% BSA) control for 30 min., 4 hr., or 48 hr in three independent experiments. Chronic GH treatment induces metabolic changes consistent with insulin resistance in 3T3-F442A adipocytes. Keywords: time-course

2005-12-20 | GSE2120 | GEO

Glucocorticoid target genes in 3T3-L1 adipocytes

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Maternal Diet Enriched with Alpha Linolenic or Saturated Fatty Acids Differentially Regulates Gene Expression in Mice Offspring's liver.

Project description:Lipid metabolic disarray in young and adult mice offspring's liver is induced by saturated fatty acids (SFA) but prevented by alpha linolenic acid (ALA, 18:3 ω3) in the maternal diet during pregnancy and lactation. The aim of the present study was to analyse the impact of maternal dietary ALA on the liver gene expression in the new-born offspring in comparison to a SFA diet. Methods: C57Bl6/J dams were fed with diets normal in calories but rich in ALA or SFA before mating and during pregnancy. Pups were sacrificed at birth and liver parameters were assessed. Gene expression was characterized by microarray analysis and validated by real time qPCR. Results: ALA compared to SFA in maternal diets during pregnancy, increased polyunsaturated fatty acids while differentially modified fatty acid desaturase activities in offspring liver. Overall, 474 and 662 genes from born pups’ liver, were differentially regulated by ALA and SFA compared to control diet (p<0.05; Fold change 2), respectively. Notably, Per3 was up-regulated by ALA whereas down-regulated by SFA, compared to control diet. Conclusions: ALA and SFA enriched diets differentially affect gene expression pattern in the offspring’s liver. ALA in particular, upregulates genes associated to low adiposity.

2018-09-06 | GSE72924 | GEO

Expression data from differentiated 3T3-L1 pre-adipocytes.

Project description:Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme catalyzing the conversion of saturated fatty acids palmitate and stearate to monounsaturated fatty acids palmitoleate and oleate. During adipocyte differentiation, SCD expression increases concomitantly with several transcription factors and lipogenic genes. We used microarrays to examine gene expression in differentiated pre-adipocytes treated with and without an SCD inhibitor. On day 7 of adipocyte differentiation, total RNA was extracted from adipocytes. Two conditions were selected for comparison: total RNA extracted from adipocytes treated with DMSO (control) and or a SCD inhibitor.

2014-04-04 | E-GEOD-51905 | biostudies-arrayexpress

Gene expression data from pre-adipocytes 3T3-L1 treated with Tsuruazuki Extract (Tsuru)

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2024-09-30 | GSE278053 | GEO

Whole genome bisulfite sequencing of 3T3-L1 preadipocytes and adipocytes

Project description:Examination of 2 samples derived from 3T3-L1 preadipocytes and adipocytes

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Gene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes

Project description:Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes.

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Gene expression signatures in IRF7 overexpressed 3T3-L1 adipocytes

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