Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Metagenomes of maternal and infant faecal samples

PROVIDER: PRJNA810575 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18150541_1.fastq.gz	Fastqsanger.gz
	SRR18150541_2.fastq.gz	Fastqsanger.gz
	SRR18150542_1.fastq.gz	Fastqsanger.gz
	SRR18150542_2.fastq.gz	Fastqsanger.gz
	SRR18150543_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 88

Similar Datasets

human gut metagenome

Project description:Early-life metagenomes from human infant fecal samples with matched maternal sample

| PRJNA698986 | ENA

Longitudinal fecal metabolomic profiles from mothers and their infants in the EDIA study

Project description:In a cohort consisting of 32 mother-infant dyads, we profiled the fecal metabolome at birth and at 3 and 6 months of infant age. Metagenomes from the same samples were also generated.

2022-08-02 | ST002246 | MetabolomicsWorkbench

Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models

Project description:Maternal obesity during pregnancy is associated with neurodevelopmental disorder (NDD) risk. We utilized integrative multi-omics to examine maternal obesity effects on offspring neurodevelopment in rhesus macaques by comparison to lean controls and two interventions. Differentially methylated regions (DMRs) from longitudinal maternal blood-derived cell-free fetal DNA (cffDNA) significantly overlapped with DMRs from infant brain. The DMRs were enriched for neurodevelopmental functions, methylation-sensitive developmental transcription factor motifs, and human NDD DMRs identified from brain and placenta. Brain and cffDNA methylation levels from a large region overlapping mir-663 correlated with maternal obesity, metabolic and immune markers, and infant behavior. A DUX4 hippocampal co-methylation network correlated with maternal obesity, infant behavior, infant hippocampal lipidomic and metabolomic profiles, and maternal blood measurements of DUX4 cffDNA methylation, cytokines, and metabolites. We conclude that in this model, maternal obesity was associated with changes in the infant brain and behavior, and these differences were detectable in pregnancy through integrative analyses of cffDNA methylation with immune and metabolic factors.

2022-08-23 | GSE171064 | GEO

Maternal BCG scar is associated with enhanced infant proinflammatory responses

Project description:Prenatal exposures such as infections and immunisation may influence infant responses. We had an opportunity to undertake an analysis of responses in infants within the context of a study investigating the effects of maternal mycobacterial exposures and infection on bacille Calmette-Guerin (BCG) vaccine-induced responses in Ugandan infants. Gene expression profiles for pathways associated with maternal LTBI and with maternal BCG scar were examined using samples collected at one (n=42) and six (n=51) weeks after BCG immunisation using microarray. Interferon and inflammation response pathways were up-regulated in infants of mothers with LTBI at six weeks, and in infants of mothers with a BCG scar at one and six weeks after BCG immunisation. Maternal BCG scar had a stronger association with infant responses than maternal LTBI, with an increased proinflammatory immune profile.

2016-10-12 | GSE87801 | GEO

Paradoxical neurobehavioral rescue by cues associated with infant trauma: Amygdala 5-HT and CORT

Project description:We show that infant trauma, as modeled by infant paired odor-shock conditioning, results in later life depressive-like behavior that can be modulated by learned infant cues (i.e., odor previously paired with shock). We have previously shown that this infant attachment odor learning paradigm results in the creation of a new artificial maternal odor that is able to control pup behavior and retain its value throughout development. Here, we assess the mechanism by which this artificial maternal odor is able to rescue depressive-like behavior and show that this anti-depressant like effect results in glucocorticoid and serotonin (5-HT) related changes in amygdala gene expression and is dependent on amygdala 5-HT. Furthermore, increasing amygdala 5-HT and blocking corticosterone (CORT) in the absence of odor mimics the adult rescue effects elicited by the artificial maternal odor, suggesting a mechanism by which odor presentation exerts its repair effects. There are three experimental groups: 1: pups with no infant shock and the adult forced swim test (FST)with no odor; 2. pups with infant odor-shock pairing and the adult forced swim test (FST) with no odor; 3. pups with infant odor-shock pairing and adult forced swim test with infant odor.

2015-02-04 | E-GEOD-58548 | biostudies-arrayexpress

NeoM Study Metagenomic Samples

Project description:Metagenomic reads for the microbiota of premature infant faecal samples

| PRJEB24015 | ENA

Project description:Maternal - infant microbiomes

| PRJNA503194 | ENA

Bioactive RNA in Maternal Breastmilk

Project description:Describe the changing landscape of milk microRNA levels over time, and their relationships to maternal and infant health

2022-01-11 | GSE192543 | GEO

DFM-Healthy

Project description:Dromedary Faecal Metagenomes-Healthy

| PRJEB8036 | ENA