Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

ABSTRACT: Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

PROVIDER: PRJNA812053 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Assessing placental maturity through histological and transcriptomic analyses in idiopathic spontaneous preterm birth

Project description:Assessing placental maturity through histological and transcriptomic analyses in idiopathic spontaneous preterm birth

2019-12-25 | GSE118442 | GEO

Human Placental Transcriptome and fetal sex differences in Spontaneous Preterm Birth

Project description:Placental insufficiency is implicated in spontaneous preterm birth (SPTB). We performed RNA-seq study in male and female placentas from women (African American, self-identified) with SPTB (< 36 weeks gestation) compared to normal pregnancies (≥ 38 weeks gestation) to assess the alterations in gene expression profiles.

2021-08-18 | GSE174415 | GEO

Characterization of methylation profiles in spontaneous preterm birth placental villous tissue

Project description:Genome wide DNA methylation profiling of normal and pathological placental villous tissue samples. The Illumina EPIC Human DNA methylation Beadchip was used to obtain DNA methylation profiles.

2023-01-12 | GSE197795 | GEO

RNA-seq analysis of human placenta to elucidate the pathomechanism of spontaneous preterm birth

Project description:The pathogenesis of spontaneous preterm birth (PTB) is largely unknown. We conducted RNA-seq transcriptomic analysis, qRT-PCR and ELISA on fresh placental villous tissue from 20 spontaneous preterm and 20 spontaneous term deliveries, to identify genes and signalling pathways involved in the pathogenesis of PTB. Our differential gene expression, gene ontology and pathway analysis revealed several dysregulated genes, including OCLN, OPTN, KRT7, WNT7A, RSPO4, BAMBI, NFATC4, SLC6A13, SLC6A17, SLC26A8 and KLF8, associated with altered trophoblast functions. We identified dysregulated Wnt, oxytocin and cellular senescence signalling pathways in preterm placentas, where augmented Wnt signalling could play a pivotal role in the pathogenesis of PTB due to its diverse biological functions. We provide fresh molecular insight into the pathogenesis of spontaneous PTB, which may drive further studies to develop new predictive biomarkers and therapeutics.

2022-10-24 | GSE211927 | GEO

Biochemistry of spontaneous preterm birth

Project description:Biochemistry of spontaneous preterm birth

| PRJNA493125 | ENA

miRNA-Seq of human placenta: spontaneous preterm birth in the presence of intra-amniotic infection/inflammation and controls

Project description:Using RNA-sequencing (RNA-Seq and miRNA-Seq), we analyzed paired villous trophoblast and decidual basalis transcriptomes of 15 women pregnant with singleton gestations grouped as follows: (1) spontaneous preterm birth (PTB) in the setting of amniocentesis-proven intra-amniotic infection (IAI) and histological chorioamnionits (n=5; GA median [range]: 26 [25-31] weeks); (2) spontaneous idiopathic preterm birth (iPTB, n=5, GA: 32 [30-33] weeks); and (3) term normal pregnancy, that delivered a heathy infant by cesarean section in the absence of labor (n=5; GA: 39 [38-39] weeks). The primary goal of this study was to identify differentially expressed transcripts and illuminate molecular mechanisms distinguishing IAI-associated PTBs from spontaneous PTBs in the absence of IAI. We further compared iPTB specimens to term specimens to determine genes differentially regulated with advancing gestational age and following spontaneous PTB without IAI. Finally, we determined transcripts selectively expressed in either the villous trophoblast or decidua basalis in each clinical context. Raw data for this series are not available because consent forms do not allow for public access to raw data.

2016-06-14 | E-GEOD-73713 | biostudies-arrayexpress

RNA-Seq of human placenta: spontaneous preterm birth in the presence of intra-amniotic infection/inflammation and controls

Project description:Using RNA-sequencing (RNA-Seq and miRNA-Seq), we analyzed paired villous trophoblast and decidual basalis transcriptomes of 15 women pregnant with singleton gestations grouped as follows: (1) spontaneous preterm birth (PTB) in the setting of amniocentesis-proven intra-amniotic infection (IAI) and histological chorioamnionits (n=5; GA median [range]: 26 [25-31] weeks); (2) spontaneous idiopathic preterm birth (iPTB, n=5, GA: 32 [30-33] weeks); and (3) term normal pregnancy, that delivered a heathy infant by cesarean section in the absence of labor (n=5; GA: 39 [38-39] weeks). The primary goal of this study was to identify differentially expressed transcripts and illuminate molecular mechanisms distinguishing IAI-associated PTBs from spontaneous PTBs in the absence of IAI. We further compared iPTB specimens to term specimens to determine genes differentially regulated with advancing gestational age and following spontaneous PTB without IAI. Finally, we determined transcripts selectively expressed in either the villous trophoblast or decidua basalis in each clinical context. Raw data for this study are not available because consent forms do not allow for public access to raw data.

2016-06-14 | E-GEOD-73712 | biostudies-arrayexpress

Human Placental Transcriptome and fetal sex differences in Spontaneous Preterm Birth

Project description:Human Placental Transcriptome and fetal sex differences in Spontaneous Preterm Birth

| PRJNA729769 | ENA

miRNA-Seq of human placenta: spontaneous preterm birth in the presence of intra-amniotic infection/inflammation and controls

2016-06-14 | GSE73713 | GEO

RNA-Seq of human placenta: spontaneous preterm birth in the presence of intra-amniotic infection/inflammation and controls

2016-06-14 | GSE73712 | GEO