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Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [ATAC-seq]

ABSTRACT: Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [ATAC-seq]

PROVIDER: PRJNA812329 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR18210044_1.fastq.gz	Fastqsanger.gz
	SRR18210044_2.fastq.gz	Fastqsanger.gz
	SRR18210045_1.fastq.gz	Fastqsanger.gz
	SRR18210045_2.fastq.gz	Fastqsanger.gz
	SRR18210046_1.fastq.gz	Fastqsanger.gz

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Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury.

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Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [H3K27ac ChIP-seq]

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Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [ChIP-seq]

Project description:Purpose: To explore whether the differences in chromatin occupancy of RXRα correlate with distinct gene expression in PTCs of MI and SI Methods: Proximal tubules were isolated for RXRα ChIP-seq Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10). Conclusions: We mapped the chromatin occupancy of RXRα.

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Activation of RXRα reprograms chromatin accessibility to protect against acute kidney injury [ATAC-seq]

Project description:Purpose: To explore the differences in chromatin openness of PTCs between MI and SI Methods: Kidney proximal tubules were isolated for ATAC-seq Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10).

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Project description:Purpose: To explore whether the differences in chromatin openness correlate with distinct gene expression in PTCs of MI and SI Methods: Proximal tubules were isolated for RNA-seq Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10). Approximately 2%-13% of the transcripts showed differential expression within the different groups, with a fold change >= 1.5 and p value <0.05.

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Project description:Purpose: To explore the differences in H3K27ac distribution in PTCs after MI and SI Methods: Proximal tubules were isolated for H3K27ac ChIP-seq Results: Using an optimized data analysis workflow, we mapped reads to the mouse genome (mm10). Conclusions: We mapped the chromatin occupancy of H3K27ac.

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