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Systematic fine-mapping and functional studies of prostate cancer risk variants [Hi-C]

ABSTRACT: Systematic fine-mapping and functional studies of prostate cancer risk variants [Hi-C]

PROVIDER: PRJNA812334 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18210117_1.fastq.gz	Fastqsanger.gz
	SRR18210117_2.fastq.gz	Fastqsanger.gz
	SRR18210118_1.fastq.gz	Fastqsanger.gz
	SRR18210118_2.fastq.gz	Fastqsanger.gz

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Systematic fine-mapping and functional studies of prostate cancer risk variants [Hi-C]

Project description:To date, genome-wide association studies (GWAS) have revealed over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants in gene regulatory regions remain elusive. Identification of causal variants and their targets from association signals relevant to prostate cancer is complicated by high linkage disequilibrium and limited availability of functional genomics data for specific tissue/cell types. Here, we integrated statistical fine-mapping and functional annotation from prostate-specific epigenomic profiles, high resolution 3D genome features, and quantitative trait loci data to distinguish causal variants from associations and identify target genes they regulate. Our fine-mapping analysis yielded 1,892 likely causal variants, and multiscale functional annotation linked them to 406 target genes. We prioritized rs10486567, located in an enhancer, as a genome-wide top-ranked SNP and predicted HOTTIP as its target. Deletion of the rs10486567-associated enhancer in prostate cancer cells decreased their capacity for invasive migration. HOTTIP overexpression in an enhancer-KO cell line rescued defective invasive migration. Furthermore, we found that rs10486567 regulates HOTTIP through allele-specific long- range chromatin interaction.

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Systematic fine-mapping and functional studies of prostate cancer risk variants [RNA-seq]

Project description:Systematic fine-mapping and functional studies of prostate cancer risk variants [RNA-seq]

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Systematic fine-mapping and functional studies of prostate cancer risk variants [ChIP-seq]

Project description:Systematic fine-mapping and functional studies of prostate cancer risk variants [ChIP-seq]

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Systematic fine-mapping and functional studies of prostate cancer risk variants

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-24 | GSE197820 | GEO

Systematic fine-mapping and functional studies of prostate cancer risk variants.

Project description:To date, genome-wide association studies (GWAS) have revealed over 200 genetic risk loci associated with prostate cancer; yet, true disease-causing variants remain elusive. Identification of causal variants and their targets from association signals is complicated by high linkage disequilibrium and limited availability of functional genomics data for specific tissue/cell types. Here, we integrated statistical fine-mapping and functional annotation from prostate-specific epigenomic profiles, 3D genome features, and quantitative trait loci data to distinguish causal variants from associations and identify target genes. Our fine-mapping analysis yielded 3,395 likely causal variants, and multiscale functional annotation linked them to 487 target genes. We prioritized rs10486567 as a genome-wide top-ranked SNP and predicted HOTTIP as its target. Deletion of the rs10486567-associated enhancer in prostate cancer cells decreased their capacity for invasive migration. HOTTIP overexpression in enhancer-KO cell lines rescued defective invasive migration. Furthermore, we found that rs10486567 regulates HOTTIP through allele-specific long-range chromatin interaction.

| S-EPMC10121464 | biostudies-literature

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