Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

ABSTRACT: Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

PROVIDER: PRJNA813346 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18250000.fastq.gz	Fastqsanger.gz
	SRR18250001.fastq.gz	Fastqsanger.gz
	SRR18250002.fastq.gz	Fastqsanger.gz
	SRR18250003.fastq.gz	Fastqsanger.gz
	SRR18250004.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 107

Similar Datasets

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

Project description:Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing. Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds. We discovered that infusing young CSF directly into aged brains improves memory function. Unbiased transcriptome analysis of the hippocampus identified oligodendrocytes to be most responsive to this rejuvenated CSF environment. We further showed that young CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and differentiation in the aged hippocampus and in primary OPC cultures. Using SLAMseq to metabolically label nascent mRNA, we identified serum response factor (SRF), a transcription factor that drives actin cytoskeleton rearrangement, as a mediator of OPC proliferation following exposure to young CSF. With age, SRF expression decreases in hippocampal OPCs, and the pathway is induced by acute injection with young CSF. We screened for potential SRF activators in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is sufficient to induce OPC proliferation and long-term memory consolidation in aged mice while Fgf17 blockade impairs cognition in young mice. These findings demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the ageing brain.

2022-05-11 | GSE198008 | GEO

Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.

Project description:Recent understanding of how the systemic environment shapes the brain throughout life has led to numerous intervention strategies to slow brain ageing1-3. Cerebrospinal fluid (CSF) makes up the immediate environment of brain cells, providing them with nourishing compounds4,5. We discovered that infusing young CSF directly into aged brains improves memory function. Unbiased transcriptome analysis of the hippocampus identified oligodendrocytes to be most responsive to this rejuvenated CSF environment. We further showed that young CSF boosts oligodendrocyte progenitor cell (OPC) proliferation and differentiation in the aged hippocampus and in primary OPC cultures. Using SLAMseq to metabolically label nascent mRNA, we identified serum response factor (SRF), a transcription factor that drives actin cytoskeleton rearrangement, as a mediator of OPC proliferation following exposure to young CSF. With age, SRF expression decreases in hippocampal OPCs, and the pathway is induced by acute injection with young CSF. We screened for potential SRF activators in CSF and found that fibroblast growth factor 17 (Fgf17) infusion is sufficient to induce OPC proliferation and long-term memory consolidation in aged mice while Fgf17 blockade impairs cognition in young mice. These findings demonstrate the rejuvenating power of young CSF and identify Fgf17 as a key target to restore oligodendrocyte function in the ageing brain.

| S-EPMC9377328 | biostudies-literature

Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus

Project description:Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus

| PRJNA575646 | ENA

Young and aged mouse bladders

Project description:Young and aged mouse bladders

| PRJNA629290 | ENA

Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 3]

Project description:Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 3]

| PRJNA718967 | ENA

Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 2]

Project description:Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 2]

| PRJNA718968 | ENA

Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 1]

Project description:Environmental enrichment restores a young DNA methylation landscape in the aged mouse hippocampus [Experiment 1]

| PRJNA718969 | ENA

sperm proteome of aged and young males

Project description:we build the sperm proteome profile of aged and young males

2022-07-12 | PXD035466 |

scRNAseq of spleen and atherosclerotic plaques from young and aged healthy and young and aged atherosclerotic mice

Project description:T cells change substantially with age and are involved in atherosclerosis. Aging is the strongest clinical risk factor for atherosclerosis so we profiled T cells in young and aged mice prior to atherosclerosis (healthy) and in young and aged atherosclerotic mice (diseased).

2023-08-22 | GSE210719 | GEO

Aged, Young and Restored Samples from Mobilized Peripheral Blood [mRNA]

Project description:We report the gene expression changes in mobilized peripheral blood in aged, young, and aged/young samples cocultured in transwell. Restored samples refer to aged MPB co-cultured with young MPB in the transwell culture

2021-12-01 | GSE138563 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data