Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Diversity of astrocytes across the mouse CNS [bulk RNA-seq]

ABSTRACT: Diversity of astrocytes across the mouse CNS [bulk RNA-seq]

PROVIDER: PRJNA813446 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Diversity of astrocytes across the mouse CNS

Project description:Diversity of astrocytes across the mouse CNS

| PRJNA813438 | ENA

Diversity of astrocytes across the mouse CNS [scRNA-seq]

Project description:Diversity of astrocytes across the mouse CNS [scRNA-seq]

| PRJNA813443 | ENA

Diversity of astrocytes across the mouse CNS [scRNA-seq]

Project description:We assessed astrocyte diversity in the cortex, hippocampus, and striatum using sing cell RNA-seq (scRNA-seq). We also assessed cortical astrocytes in wild type control and transgenic APP/PS1dE9 mice using scRNA-seq.

2022-09-19 | GSE198027 | GEO

Diversity of astrocytes across the mouse CNS [bulk RNA-seq]

Project description:We assessed astrocyte transcriptomic signatures using RiboTag methods in 13 CNS regions.

2022-09-19 | GSE198024 | GEO

MAFG-driven astrocytes promote CNS inflammation

Project description:MAFG-driven astrocytes promote CNS inflammation

| PRJNA534022 | ENA

Mouse primary astrocytes: LCN2 protein treated vs. control

Project description:Transcriptional profiling of mouse primary astrocytes comparing control untreated astrocytes with astrocytes treated with recombinant LCN2 protein (10 micro gram/ml). Goal was to determine the effects of LCN2 treatment on global gene expression in astrocytes. A secreted protein lipocalin-2 (LCN2) has been implicated in diverse cellular processes including cell morphology and migration. We have previously demonstrated that lcn2 mediates reactive astrocytosis. In order to further understand the role of lcn2 in the CNS, astrocyte transcriptome was analyzed following LCN2 treatment. Chemokines were the major group of genes upregulated by LCN2. Two-condition experiment, control untreated astrocytes vs. LCN2 protein treated astrocytes. Biological replicates: 1 control replicates, 1 treated replicates.

2012-06-29 | E-GEOD-15667 | biostudies-arrayexpress

RNA-seq and TRAP-seq of astrocytes and brain tissue in mouse models of Alzheimer's pathology

Project description:Alzheimer’s disease is known to alter astrocytes, but the effect of Aß and Tau pathology on these cells remains poorly understood. We investigated the transcriptomic behaviour of astrocytes (via translating ribosome affinity purification (TRAP)), and bulk brain tissue, in mouse models of APP/PS1 ß-amyloidopathy and MAPT-P301S tauopathy, in a mouse model overexpressing cytoprotective Nrf2 specifically in astrocytes (GFAP-Nrf2 model), and in crosses between the amyloidopathy and tauopathy models with the GFAP-Nrf2 mouse.

2021-12-02 | E-MTAB-10985 | biostudies-arrayexpress

Mouse primary astrocytes: LCN2 protein treated vs. control

2012-06-30 | GSE15667 | GEO

Bulk RNA-seq of FACS sorted astrocytes upon microglial depletion

Project description:As the professional phagocyte in the central nervous system (CNS), microglia are the primary scavenger removing cell corpses. The failure of microglia in debris clearance influences the normal CNS function. Meanwhile, microglia undergo turnover during the whole lifespan. If dead microglia are not timely removed, accumulated corpses may influence the CNS function. The microglial corpse clearance is hereby crucial for CNS homeostasis. However, the underlying mechanism remains obscure. In this study, we investigated how microglial corpses are removed. We found that microglial corpses are mainly phagocytosed by astrocytes, mediated by C4b opsonization. Then engulfed microglial fragments are degraded in astrocytes via the RUBICON-dependent LC3-associated phagocytosis (LAP), a form of non-canonical autophagy. The interference of the C4b-mediated engulfment and its subsequent LAP disrupt the microglial debris removal and degradation, respectively. Together, we elucidated cellular and molecular mechanisms of microglial debris removal, extending the knowledge on how the CNS homeostasis is maintained.

2022-09-01 | GSE171321 | GEO

Astrocytes from mouse NSCs

Project description:Astrocytes from mouse NSCs

| PRJNA595476 | ENA