Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic Responses of Mycoplasma bovis upon Treatments of trans-Cinnamaldehyde, Carvacrol, and Eugenol

ABSTRACT: Transcriptomic Responses of Mycoplasma bovis upon Treatments of trans-Cinnamaldehyde, Carvacrol, and Eugenol

PROVIDER: PRJNA813586 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18260216_1.fastq.gz	Fastqsanger.gz
	SRR18260216_2.fastq.gz	Fastqsanger.gz
	SRR18260217_1.fastq.gz	Fastqsanger.gz
	SRR18260217_2.fastq.gz	Fastqsanger.gz
	SRR18260218_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 48

Similar Datasets

Transcriptomic Responses of Mycoplasma bovis upon Treatments of trans-Cinnamaldehyde, Carvacrol, and Eugenol

Project description:Through RNA sequencing, we report here that Carvacrol (CAR) affected the expression of 153 genes which included the down-regulation of energy generation-related proteins, pentose phosphate pathway, and up-regulation of ribosomes and translation-related proteins. Few differentially expressed genes were found when M. bovis were treated with Trans-cinnamaldehyde (TC), Eugenol (EU), or Carvacrol (CAR) when the three PDAs were double or triple combined. Our results suggest that, as opposed to the effect of CAR, the growth inhibitory effects of TC and EU at levels tested may be exerted through mechanisms other than gene expression regulations.

2022-06-09 | GSE198086 | GEO

Gene expression response of Salmonella enterica serovar Enteritidis phage type 8 to subinhibitory concentrations of trans-cinnamaldehyde and eugenol

Project description:Transcriptional profiles of mid-exponentially growing Salmonella enterica sv Enteritidis PT8 cultures in response to exposure to trans-cinnamaldehyde (0.01%; 0.75mM) or eugenol (0.04%; 2.46mM)

2017-11-09 | GSE102477 | GEO

Comprehensive Immunoproteome of Mycoplasma bovis

Project description:This study was aimed to elucidate a global antigenic profile of Mycoplasma bovis (M. bovis) with immunoproteomics, immunoinformatics, and gene expression approaches. The extracts of whole-cell proteins and TX-114 membrane fraction of a Chinese strain M. bovis HB0801 were separated with two dimensional gel electrophoresis (2-DE) and proteins reacting with antisera to M. bovis from experimentally infected calves were detected by MALDI-TOF MS.

2016-06-13 | PXD003479 | Pride

Transcriptomic Responses of Mycoplasma bovis Upon Treatments of trans-Cinnamaldehyde, Carvacrol, and Eugenol

Project description:Mycoplasma bovis (M. bovis) is an insidious, wall-less primary bacterial pathogen that causes bovine pneumonia, mid-ear infection, mastitis, and arthritis. The economic losses caused by M. bovis due to culling, diminished milk production, and feed conversion are underestimated because of poor diagnosis/recognition. Treatment with common antibiotics targeting the cell wall is ineffective. Plant-derived antimicrobials (PDAs) such as food-grade trans-cinnamaldehyde (TC), eugenol (EU), and carvacrol (CAR) are inexpensive and generally regarded as safe for humans and animals yet possess strong anti-bacterial properties. In preliminary studies, we found that all three PDAs inhibited the growth of M. bovis in vitro. Through RNA sequencing, we report here that CAR affected the expression of 153 genes which included the downregulation of energy generation-related proteins, pentose phosphate pathway, and upregulation of ribosomes and translation-related proteins. Few differentially expressed genes were found when M. bovis was treated with TC, EU, or when the three PDAs were double or triple combined. Our results suggest that, as opposed to the effect of CAR, the growth-inhibitory effects of TC and EU at levels tested may be exerted through mechanisms other than gene expression regulations.

| S-EPMC9207385 | biostudies-literature

microRNA identification in the Mycoplasma bovis infected mammary gland tissue in Holstein Friesian cattle

Project description:The immune response associated with mastitis caused by Mycoplasma bovis is a very complicated biological process in several type of cells, including immune cells, mammary epithelial cells and, endothelial cells. Thus, revealing of the microRNAs in the Mycoplasma bovis infected mammary gland tissues is particularly important for the immune response mechanism to Mycoplasma bovis. Firstly, mammary gland tissue samples were collected from Holstein cows and screened for Mycoplasma bovis. Then, total RNA was isolated from mycoplasma bovis infected tissues and RNA sequencing was performed. After bioinformatics analysis, GO and KEGG analysis of target genes of identified microRNAs were conducted. Our results revaled that 24 of the known microRNAs were expressed differently and 13 of the novel microRNAs were expressed differently in Mycoplasma bovis positive tissues. The target genes of these microRNAs were found to be associated with especially inflammation pathways. In conclusion, this study demonstrated that identified miRNAs may be involved in the signaling pathways during mastitis case caused by Mycoplasma bovis.

2021-05-25 | GSE152865 | GEO

Toxicogenomic response of Mycobacterium bovis to disinfectant treatments

Project description:This SuperSeries is composed of the following subset Series: GSE13423: Microarray Analysis of Toxicogenomic Effects of Sodium Hypochlorite on Mycobacterium bovis BCG GSE14272: Microarray Analysis of Toxicogenomic Effects of Hydrogen Peroxide on Mycobacterium bovis BCG Refer to individual Series

2009-01-19 | E-GEOD-14349 | biostudies-arrayexpress

Differential expressed proteins between Mycoplasma bovis different strains

Project description:Comparing differential expressed proteins between Mycoplasma bovis different strains by using label-free method

2020-06-15 | PXD017374 | Pride

Transcription profiling of bovine neutrophils stimulated with Mycoplasma bovis against untreated controls

Project description:Mycoplasma species are highly contagious pathogens, and Mycoplasma infectious disease are a serious issue for the dairy industry. The bovine neutrophils play an important role for the eradication of pathogens which cause mycoplasmal infection, however the effects of M. bovis for immune response of neutrophils have not been fully clarified. We examined the transcription profiling of bovine neutrophils on the stimulation with M. bovis for 3h (3 stimuli, 3 control).

2020-11-30 | E-MTAB-9022 | biostudies-arrayexpress

Genome-wide Analysis of mRNAs and lncRNAs in Mycoplasma Bovis infected and non-infected bovine mammray gland tissues.

Project description:Mycoplasma bovis (M. bovis) causes to the diseases such as arthritis, pneumonia, abortion and mastitis causing to great losses in dairy bovine industries. It undertakes significant functions in the regulation of the immune response formed by many RNA type bacteria such as Messenger RNA (mRNAs) and Long noncoding RNA (lncRNAs). mRNA and lncRNA expression profiles still cannot be majorly known in the bovine mammary gland tissues infected with M. bovis. To illuminate this issue, transcription analysis has been conducted regarding mRNA and IncRNAs in the breast tissues belonging to Holstein cattle infected and not infected with M. Bovis. Differently expressed 1310 mRNAs and 57 IncRNAs have been determined in the bovine mammary gland tissues infected and not infected with M. Bovis. In addition; 392 novel lncRNAs have been detected. Also; it has been found that 19 novel lncRNAs are expressed in a different way. It has been revealed in gene ontology analysis that the differently expressed mRNAs and IncRNAs play a significant role in many vital biological pathways such as Metabolic pathways, T cell receptor signaling pathway, TGF-beta signaling pathway, Pathways in cancer, PI3K-Akt signaling pathway, NF-kappa B signaling pathway, mTOR signaling pathway and Apoptosis including the immune response and cancer. When literature review is conducted, it is seen that this study is the first genome wide IncRNA research conducted on the infected bovine mammary gland tissues with M. bovis agent. Our results have provided bovine mammary gland IncRNA and mRNA resource to understand their roles in the regulation of the immune response against the agent of M. Bovis in the bovine mammary gland tissues.

2020-06-01 | GSE133333 | GEO

Project description:trans-cinnamaldehyde

| PRJNA879259 | ENA