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A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure [ChIP-Seq]

ABSTRACT: A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure [ChIP-Seq]

PROVIDER: PRJNA813885 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18272400.fastq.gz	Fastqsanger.gz
	SRR18272401.fastq.gz	Fastqsanger.gz
	SRR18272402.fastq.gz	Fastqsanger.gz
	SRR18272403.fastq.gz	Fastqsanger.gz
	SRR18272404.fastq.gz	Fastqsanger.gz

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A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure

Project description:A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure

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A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure [ChIP-Seq]

Project description:Purpose: To identify cohibin-dependent condensin binding sites throughout the yeast genome. Conclusions: This ChIP-seq experiment showed that the condensin subunit, Brn1, was depleted from the RDT1 promoter in an lrs4Δ mutant strain. The experiment also showed that the Lrs4 subunit of the cohibin complex is highly enriched at the RDT1 promoter on chromosome III.

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A nucleolar condensin-recruiting complex that regulates yeast chromosome III structure

Project description:This SuperSeries is composed of the SubSeries listed below.

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Project description:Purpose: This study was designed to determine the mechanism of condensin and Sir2 recruitment to the RDT1 promoter region of S. cerevisiae chromosome III, and to test whether preventing condensin recruitment by deleting the key factors, Fob1 and Lrs4, significantly alters the conformation of chromosome III. Conclusions: Conformational changes in chromosome III and loss of CEN12-rDNA looping in chromosome XII observed in lrs4? and fob1? mutants.

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Regulation of yeast chromosome III architecture and mating-type switching by a Sir2/condensin-bound region of the recombination enhancer [HiC-Seq]

Project description:Saccharomyces cerevisiae switches its mating type (MATa or MATalpha) through gene conversion using one of two possible donors, HMLalpha or HMRa, both of which are maintained by the SIR silencing complex as heterochromatic cassettes on opposing ends of chromosome III. In MATa cells, HMLalpha on the left arm is preferentially chosen as the donor through a mechanism requiring a cis-acting sequence called the recombination enhancer (RE). The left half of the RE is required for this donor preference activity, whereas the right half has been implicated in regulating chromosome III structure. In this study we have identified a MATa-specific Sir2 and condensin binding site within the right half of the RE that maintains chromosome III in a switching-competent conformation by preventing MATa from interacting with the default HMRa donor on the right arm. Within the RE, Sir2 strongly represses transcription of a small MATa-specific gene of unknown function (RDT1). Upon expression of HO endonuclease to induce the switching process, Sir2 redistributes from the RE to the double-stranded DNA break site at MATa, thus derepressing RDT1 transcription to coincide with the timing of mating-type switching. Condensin is also displaced from the RE in response to the HO-induced break, likely contributing to the transient change in chromosome III conformation required for effective switching without disruption of HML and HMR heterochromatin.

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Regulation of yeast chromosome III architecture and mating-type switching by a Sir2/condensin-bound region of the recombination enhancer [ChIP-Seq]

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FuHsi Maintains Nucleolar Structure and Initiates Nucleolar Biogenesis.

Project description:FuHsi Maintains Nucleolar Structure and Initiates Nucleolar Biogenesis.

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Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III [Micro-C seq]

Project description:Fob1-dependent condensin recruitment and loop extrusion on yeast chromosome III [Micro-C seq]

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