Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Type I interferons govern Zika virus resistance of human macrophages and microglia

ABSTRACT: Type I interferons govern Zika virus resistance of human macrophages and microglia

PROVIDER: PRJNA815844 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18318423.fastq.gz	Fastqsanger.gz
	SRR18318424.fastq.gz	Fastqsanger.gz
	SRR18318425.fastq.gz	Fastqsanger.gz
	SRR18318426.fastq.gz	Fastqsanger.gz
	SRR18318427.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Type I interferons govern Zika virus resistance of human macrophages and microglia

Project description:The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Therapeutic manipulation of the IFN-I system may bring clinical benefit in ZIKV.

2022-10-31 | GSE198542 | GEO

Microglia regulate Zika virus infection in human developing brain and glioma

Project description:This paper shows that, whereas SOX2+ cells in HDB are highly susceptible to ZKV, SOX2+ primary GBM samples exhibit moderate to high resistance to infection. These datasets address the reasons for this difference, based on infection of primary patient GBM and human developing brain samples with mCherry Zika reporter virus, then FACS sorting the Zika-mCherry positive and negative fractions from each sample for bulk RNA-Sequencing. The primary finding of importance is that Zika resistant GBMs exhibit an immune signature reflecting high levels of infiltration by microglia which are present only in small numbers or absent altogether in human developing brain.

2022-09-08 | GSE178621 | GEO

Glioblastoma stem cells infected by ZIKA virus

Project description:We repoted the Glioblastoma stem cells(GSCs) infected by two strains of ZIKA virus, the Brazil and Dakar strains. The ZIKV was added into the medium of GSCs for 48 hours, the RNA was harvested after ZIKV infection. We found that the GSCs up-regulated the Type 1&2 interferons after infected by ZIKV

2017-08-23 | GSE102924 | GEO

Eutherian interferons

Project description:Eutherian interferons

| PRJEB36709 | ENA

Microglia regulate Zika virus infection in human developing brain and glioma

Project description:Microglia regulate Zika virus infection in human developing brain and glioma

| PRJNA739736 | ENA

ImmGen Cytokines: Interferons

Project description:ImmGen Cytokines: Interferons

| PRJNA303161 | ENA

Genome-Wide Expression Profiling of human tumor-infiltrating microglia/macrophages

Project description:Microglia isolated from glioma patients gain anti-tumor activities upon poly (I:C) stimulation. Expression profiles of human tumor-infiltrating microglia/macrophages before (untreated) and after treatment with poly (I:C) for 48h (induced). Tumor-infiltrating microglia/macrophages were isolated from freshly excised brain tumors

2011-12-31 | E-GEOD-25289 | biostudies-arrayexpress

Microarray analysis of MRC-5 cells infected with Zika virus strains

Project description:To better understand the critical drivers of Zika virus pathogenicity, we used microarray analysis to evaluate the host responses triggered by Zika virus infection in MRC-5 cells.

2021-03-23 | E-MTAB-10292 | biostudies-arrayexpress

RNA-seq transcript and gene data on zika exposed and zika naïve samples

Project description:RNA-seq count data at 3 timepoints was generated for Zika-exposed and Zika-naïve individuals in order to assess associated signatures

2019-04-17 | GSE129882 | GEO

Zika genome

Project description:Zika genome

| PRJEB34688 | ENA