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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (GFP:mCherry 1:1 4T07 mix tumors after Jedi killing Bulk RNA)

ABSTRACT: Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (GFP:mCherry 1:1 4T07 mix tumors after Jedi killing Bulk RNA)

PROVIDER: PRJNA816526 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18333131_1.fastq.gz	Fastqsanger.gz
	SRR18333131_2.fastq.gz	Fastqsanger.gz
	SRR18333132_1.fastq.gz	Fastqsanger.gz
	SRR18333132_2.fastq.gz	Fastqsanger.gz
	SRR18333133_1.fastq.gz	Fastqsanger.gz

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Project description:Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

| PRJNA816518 | ENA

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (GFP:mCherry 1:1 4T07 mix tumors after Jedi killing Bulk RNA)

Project description:Immunotherapy is a promising treatment for Triple-Negative Breast Cancer (TNBC), but patients recur, arising the need to understand mechanisms of resistance. We discovered that in primary breast cancer, tumor cells that survive T-cell attack are in a quiescent state. Quiescent Cancer Cells (QCCs) are found clustering together forming regions with reduced immune infiltration. QCCs display superior tumorigenic capacity and higher expression of stemness genes than their proliferative counterparts. We adapted single-cell-RNA-sequencing with precise spatial resolution to profile infiltrating cells inside and outside QCC niches. This transcriptomic analysis revealed hypoxia-induced programs and identified more exhausted T-cells, tumor-protective fibroblasts, and dysfunctional dendritic cells inside clusters of QCCs. This uncovered differential phenotypes in infiltrating cells based on their specific intra-tumor location. Thus, QCCs constitute immunotherapy-resistant reservoirs by orchestrating a local hypoxic immune-suppressive milieu that blocks T-cell function. Eliminating QCCs holds the promise to counteract resistance to immunotherapy and prevent disease recurrence in TNBC.

2022-04-20 | GSE198712 | GEO

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (PADMEseq)

Project description:Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (PADMEseq)

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (PADMEseq)

2022-04-20 | GSE198714 | GEO

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-20 | GSE198715 | GEO

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (QCC vs proliferative cells from tumors Bulk RNA)

2022-04-20 | GSE198713 | GEO

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (QCC vs proliferative cells from tumors Bulk RNA)

Project description:Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche (QCC vs proliferative cells from tumors Bulk RNA)

| PRJNA816525 | ENA

Bdellovibrio bacteriovorus attack phase and post-infection cells

Project description:Bdellovibrio bacteriovorus is a Gram-negative bacterium that is a pathogen of other Gram-negative bacteria, including many bacteria which are pathogens of humans, animals and plants. As such Bdellovibrio has potential as a biocontrol agent, or living antibiotic. B. bacteriovorus HD100 has a large genome and it is not yet known which of it encodes the molecular machinery and genetic control of predatory processes. We have tried to fill this knowledge-gap using mixtures of predator and prey mRNAs to monitor changes in Bdellovibrio gene expression at a timepoint of early-stage prey infection and prey killing in comparison to control cultures of predator and prey alone and also in comparison to Bdellovibrio growing axenically (in a prey-or host independent âHIâ manner) on artificial media containing peptone and tryptone. From this we have highlighted genes of the early predatosome with predicted roles in prey killing and digestion and have gained insights into possible regulatory mechanisms as Bdellovibrio enter and establish within the prey bdelloplast. Approximately seven percent of all Bdellovibrio genes were significantly up-regulated at 30 minutes of infection- but not in HI growth- implicating the role of these genes in prey digestion. Five percent were down-regulated significantly, implicating their role in free-swimming, attack-phase physiology. This study gives the first post- genomic insight into the predatory process and reveals some of the important genes that Bdellovibrio expresses inside the prey bacterium during the initial attack. Keywords: Transcriptional analysis 3 replicates of attack phase cells and 3 replicates of 30 minutes post-infection cells were analysed on individual arrays. Replicate 3 was normalized separately.

2010-05-18 | E-GEOD-9269 | biostudies-arrayexpress

estuary mix

Project description:estuary mix Raw sequence reads

| PRJNA957238 | ENA

short and long attack latency mice

Project description:Two wild house mice lines were genetically selected for short and long attack latency. Mice with an attack latency <50s or >600s were considered short attack latency mice (SAL) and long attack latency mice(LAL) respectively. RNA from the hippocampus of 14 SAL or 14 LAL mice was pooled and used as input material for the SAGE libraries. Keywords: other

2003-10-31 | GSE786 | GEO

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