Project description:Single-cell mRNA sequencing (mRNA-seq) technologies are reshaping the current cell-type classification system. In previous studies, we built a comprehensive mouse cell atlas to catalog all cell types by collecting scRNA-seq data in the fetal and adult stages. Howerver, systematically study for organism-level dynamic changes of cellular states across mouse life span are still lacking. Here, We made an updated version of mouse cell atlas (MCA) by adding scRNA-seq data covering 14 major mouse organs during different mouse development period. We revealed aging related regulatory networks and pathways that have not been well characterized previously. We found that the expressions of immune-related genes, such as antigen-presenting genes and immunoglobulin genes, appeared in non-immune cell types in aging process. We also focused on the expression of lung epithelial immunoglobulin genes and revealed their related transcriptional regulation mechanisms. The updated MCA resource provides a valuable resource for studying mammalian development, maturation and aging.

2022-07-23 | GSE153562 | GEO

Mapping the Drosophila developmental and aging atlas by single cell mRNA-seq

Project description:Single-cell mRNA sequencing (scRNA-seq) technologies are reshaping current cell-type classification system. In previous studies, we constructed the Mouse Cell Atlas (MCA) and Human Cell Landscape (HCL) to catalog all cell types by collecting scRNA-seq data. Howerver, the systematic study for organism-level dynamic changes of cellular states across fruit fly (Drosophila melanogaster) life span are still lacking. Here, we constructed the Drosophila cell Landscape covering different development periods using Microwell-seq protocol. The Drosophila cell landscape provides a valuable resource for studying cross-sepciess development, maturation and aging.

2022-07-23 | GSE198831 | GEO

Mapping the zebrafish developmental and aging atlas by single cell mRNA-seq

Project description:Single-cell mRNA sequencing (scRNA-seq) technologies are reshaping current cell-type classification system. In previous studies, we constructed the Mouse Cell Atlas (MCA) and Human Cell Landscape (HCL) to catalog all cell types by collecting scRNA-seq data. Howerver, the systematic study for organism-level dynamic changes of cellular states across zebrafish life span are still lacking. Here, we constructed the zebrafish cell Landscape covering different development periods using Microwell-seq protocol. The zebrafish cell landscape provides a valuable resource for studying cross-sepciess development, maturation and aging.

2022-07-23 | GSE198571 | GEO

University of Washington Developmental Single Cell Atlas

Project description:University of Washington Developmental Single Cell Atlas

| PRJNA622599 | ENA

University of Washington Developmental Single Cell Atlas

Project description:University of Washington Developmental Single Cell Atlas

| PRJNA622600 | ENA

Single cell atlas of the aging mouse trachea

Project description:Single cell atlas of the aging mouse trachea

| PRJNA1021685 | ENA

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

Project description:Single-Cell Transcriptomic Atlas of Primate Ovarian Aging