Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Adolescent bone sarcomas have distinct immune signatures and intercellular communication networks

ABSTRACT: Adolescent bone sarcomas have distinct immune signatures and intercellular communication networks

PROVIDER: PRJNA817261 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18360721_1.fastq.gz	Fastqsanger.gz
	SRR18360721_2.fastq.gz	Fastqsanger.gz
	SRR18360722_1.fastq.gz	Fastqsanger.gz
	SRR18360722_2.fastq.gz	Fastqsanger.gz
	SRR18360723_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 36

Similar Datasets

Adolescent bone sarcomas have distinct immune signatures and intercellular communication networks

Project description:Ewing and osteosarcoma are bone sarcomas that occur predominantly in adolescents. In the setting of metastatic or recurrent disease, overall prognosis is poor. While immunotherapy is effective for some adult soft tissue sarcoma, limited success has been achieved with immunotherapy for pediatric bone sarcomas. To better understand antitumor immunity in Ewing and osteosarcoma patients, we performed single-cell RNAseq on peripheral blood and tumor infiltrating immune populations using 10X Genomics droplet-based approach. We also included peripheral blood from healthy adolescent blood donors as a comparator. Utilizing these transcriptional profiles, we characterized tumor infiltrating CD8+ T cells and myeloid cells and identified intercellular communication networks in both primary and recurrent disease.

2022-08-31 | GSE198896 | GEO

Transient restriction of intercellular communication is required for root regeneration

Project description:Transient restriction of intercellular communication is required for root regeneration

2023-11-24 | GSE248204 | GEO

Cancer Communication Within Hispanic Social Networks

Project description:This trial examines cancer communication within Hispanic social networks. Hispanics have the lowest colorectal cancer screening rate of any major ethnic group and health interventions are crucially needed among Hispanics. Patient decision aids are health communication interventions designed to provide patients with targeted health information and have shown to improve colorectal cancer screening rates among Hispanics. The goal of this study is to investigate, in a sample of Hispanics, how a colorectal cancer decision aid aimed at increasing individuals’ colorectal cancer screening behavior has effects on their alters’ intention to get screened for colorectal cancer.

| 2343521 | ecrin-mdr-crc

Developmental gene regulation by an ancient intercellular communication system in social amoebae

Project description:In the social amoebae (Dictyostelia) quorum sensing system mediates aggregation of single cells into multicellular aggregates by chemotactic movement towards gradients of diffusible molecules known as acrasins. The acrasin of P. violaceum is the unusual dipeptide N-propionyl-gamma-L-glutamyl-L-ornithine-delta-lactam-ethylester, known as glorin. Phylogenetic analysis has indicated that P. violaceum is more related to the most derived group 4 dictyostelids than to the ancient group 2 polysphondylids such as P. pallidum. Nevertheless it has been reported that P. pallidum cells respond to glorin in chemotaxis assays. This has led to the assumption that glorin-based communication may be the most ancient form of intercellular communication that Dictyostelia invented to organize early steps of multicellular development. In this study we show that glorin mediates rapid changes in gene expression at the transition from vegetative growth to aggregation, apparently without pronounced cross-talk with the cyclic AMP-based communication system that coordinates post-aggregation events in this species. We describe glorin-mediated changes in gene expression in the social amoeba Polysphondylium pallidum at the transition from unicellular growth to multicellular development. Comparison of gene expression in growing cells versus cells starving for 2 or 3 hours in the presence or absence of glorin.

2010-10-29 | E-GEOD-24911 | biostudies-arrayexpress

Transient restriction of intercellular communication is required for root regeneration

Project description:Transient restriction of intercellular communication is required for root regeneration

| PRJNA1042805 | ENA

Clinical implications and molecular features of extracellular matrix networks in soft tissue sarcomas

Project description:The landscape of extracellular matrix (ECM) alterations in soft tissue sarcomas (STS) remains poorly characterised. We aimed to investigate the tumour ECM and adhesion signalling networks present in STS and their clinical implications.

2024-05-07 | PXD049373 | Pride

Clinical implications and molecular features of extracellular matrix networks in soft tissue sarcomas

2024-05-07 | PXD049383 | Pride

Reconstruction of intercellular communication and signaling impacting de novo HSC emergence using CellComm platform

Project description:Cellular transitions are shaped by cross-talk between cell-intrinsic and extrinsic factors. Signals derived from the cell’s microenvironment are integrated and processed by the cell to modulate gene expression programs to instruct cell function and fate. Recent advances in single-cell technologies and analytics have provided an unprecedented resolution to study intercellular communication and differentiation trajectories. Here, we developed CellComm, a systems biology platform to infer intercellular communication networks and transcriptional regulators downstream of cell surface receptors predicted to mediate cellular interactions. We applied CellComm to investigate how the unique cellular niche of the aorta-gonad-mesonephros (AGM) region is involved in hematopoietic stem cell emergence and identified key cell types and microenvironmental signals implicated in hematopoietic development. We extensively validated CellComm’s predictions in three different species - zebrafish, mouse and human - and found both known and novel genes involved in developmental hematopoiesis, such as Stat3, Nr0b2, Ybx1 and, surprisingly, App, which is often reported in neurodegenerative disorders. Strikingly, CellComm revealed extensive cross-talk of signaling pathways feeding into the same transcriptional regulators, indicating a tightly regulated developmental program ensuring dynamic adaptation to changes in the embryonic environment. Taken together, our work contributes to a better understanding on how the embryonic niche is involved in developmental hematopoiesis as well as provides a new algorithm and data resource for the scientific community.

2022-02-10 | GSE160526 | GEO

Developmental gene regulation by an ancient intercellular communication system in social amoebae

2010-10-29 | GSE24911 | GEO

Intercellular communication via miR-143-containing microvesicles controls osteoblastic bone formation in vivo

Project description:Intercellular communication via miR-143-containing microvesicles controls osteoblastic bone formation in vivo

| PRJNA603887 | ENA