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Comprehensive transcriptome profile of AGS gastric cancer cells treated with flavonoid prunetin

ABSTRACT: Comprehensive transcriptome profile of AGS gastric cancer cells treated with flavonoid prunetin

PROVIDER: PRJNA817523 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18364232_1.fastq.gz	Fastqsanger.gz
	SRR18364232_2.fastq.gz	Fastqsanger.gz
	SRR18364233_1.fastq.gz	Fastqsanger.gz
	SRR18364233_2.fastq.gz	Fastqsanger.gz
	SRR18364234_1.fastq.gz	Fastqsanger.gz

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Comprehensive transcriptome profile of AGS gastric cancer cells treated with flavonoid prunetin

Project description:Gastric cancer is the common type of malignancy positioned at second in mortality rate causing burden worldwide with increasing treatment options. The application of transcriptomics technologies possesses the high efficiency of identifying key metabolic pathways and functional genes in cancer research.Prunetin (PRU) is an O-methylated flavonoid that belongs to the group of isoflavone executing beneficial activities. In the current study, a transcriptome profile on treated and untreated conditions of flavonoid prunetin was performed in order identify the differential expression of genes which eventually aids in preditcing candidate biomarkers.

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mRNA profiling of AGS Gastric Cancer cell line treated with the Homeopathy formulation, Ornithogalum

Project description:Ornithogalum is one of the therapeutic formulation used in homeopathic treatments. It is specifically used in the treatment for gastric and duodenal ulcerations. Towards understanding the anticancer mechanism, we investigated the genome-wide mRNA changes upon treating AGS Gastric Cancer cells with Ornithogalum. We observed that totally 707 genes were significantly regulated upon Ornithogalum Treatment, among them 246 genes were upregulated and 461 genes were downregulated. The results provide insight into molecular implication and gene level expression of AGS upon treatment with Ornithogalum. Total RNA was isolated from AGS gastric cancer cells treated with 0.01% of ornithogalum and ethanol control and profiled using Affymetrix Human Gene 1.0 ST Array (HuGene-1_0-st).

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