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Stella regulates the development of female germline stem cells by modulating chromatin structure and DNA methylation [Hi-C_2]

ABSTRACT: Stella regulates the development of female germline stem cells by modulating chromatin structure and DNA methylation [Hi-C_2]

PROVIDER: PRJNA818288 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18398768_1.fastq.gz	Fastqsanger.gz
	SRR18398768_2.fastq.gz	Fastqsanger.gz

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Stella regulates the development of female germline stem cells by modulating chromatin structure and DNA methylation [Hi-C_2]

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<i>Stella</i> Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation.

Project description:Female germline stem cells (FGSCs) have the ability to self-renew and differentiate into oocytes. Stella, encoded by a maternal effect gene, plays an important role in oogenesis and early embryonic development. However, its function in FGSCs remains unclear. In this study, we showed that CRISPR/Cas9-mediated knockout of Stella promoted FGSC proliferation and reduced the level of genome-wide DNA methylation of FGSCs. Conversely, Stella overexpression led to the opposite results, and enhanced FGSC differentiation. We also performed an integrative analysis of chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq), high-throughput genome-wide chromosome conformation capture (Hi-C), and use of our published epigenetic data. Results indicated that the binding sites of STELLA and active histones H3K4me3 and H3K27ac were enriched near the TAD boundaries. Hi-C analysis showed that Stella overexpression attenuated the interaction within TADs, and interestingly enhanced the TAD boundary strength in STELLA-associated regions. Taking these findings together, our study not only reveals the role of Stella in regulating DNA methylation and chromatin structure, but also provides a better understanding of FGSC development.

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