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Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

ABSTRACT: Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

PROVIDER: PRJNA818713 | ENA |

REPOSITORIES: ENA

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Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

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Project description:Transcranial Electrical Stimulation has therapeutic effects on different diseases, including epilepsy. Nevertheless, previous evidence also suggest that TFS could modify protein expression in the healthy brain of rats. We aimed to screen genetic expression in the cerebral cortex and the hippocampus of healthy rats to identify potential targets of therapeutic or adverse effects of TFS.

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Gene expression analysis in human focal cortical dysplasia and tuberous sclerosis

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Repetitive transcranial magnetic stimulation induces cortical layer, brain region, and protocol dependent neural plasticity [Spatial transcriptomics]

Project description:Repetitive transcranial magentic stimulation (rTMS) is a non-invasive toll commonly used to study neural plasticity processes and treat neurological disorders. Despite the popularity of rTMS, it is still unclear what neural plasticity mechanisms are induced in the brain regions at and beyond the stimulation site, and how this varies with different rTMS protocols. Here we used spatial transcriptomics to map the neural plasticity mechanisms induced across cortical and sub-cortical regions following intermittent or continuous theta-burst stimulation protocols to the mouse sensorimotor cortex. Our results revealed that rTMS alters the expression of genes related to several cellular processes and neural plasticity mechanisms across the brain which was both brain region and rTMS protocol dependent. In the cortex, the effect of rTMS was not only dependent on the cortical region, but also the cortical layer within each cortical region. These findings uncover the neural plasticity mechanisms induced across the brain following rTMS and help inform how different stimulation protocols can be used to drive specific neural plasticity mechanisms.

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Repetitive transcranial magnetic stimulation induces cortical layer, brain region, and protocol dependent neural plasticity [Bulk RNA-seq]

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