Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

ABSTRACT: Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

PROVIDER: PRJNA818713 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Cortical and hippocampal gene expression after transcranial focal stimulation and a single seizure in rats

Project description:Transcranial Electrical Stimulation has therapeutic effects on different diseases, including epilepsy. Particularly, Transcranial Focal Stimulation (TFS) has anticonvulsive and antiepileptogenic effects. Nevertheless, the mechanisms and therapeutic targets that induced these effects remain ellusive. We aimed to screen the genetic expression in the cerebral cortex and the hippocampus of rats after a single seizure and TFS to identify potential targets.

2024-03-30 | GSE199183 | GEO

Cortical and hippocampal gene expression after transcranial focal stimulation in healthy rats

Project description:Cortical and hippocampal gene expression after transcranial focal stimulation in healthy rats

| PRJNA817801 | ENA

Cortical and hippocampal gene expression after transcranial focal stimulation in healthy rats

Project description:Transcranial Electrical Stimulation has therapeutic effects on different diseases, including epilepsy. Nevertheless, previous evidence also suggest that TFS could modify protein expression in the healthy brain of rats. We aimed to screen genetic expression in the cerebral cortex and the hippocampus of healthy rats to identify potential targets of therapeutic or adverse effects of TFS.

2024-03-30 | GSE198994 | GEO

Gene expression analysis in human focal cortical dysplasia and tuberous sclerosis

Project description:Focal cortical dysplasia (FCD), a focal brain malformation, is the most common cause of intractable epilepsy. One of the related disorders is tuberous sclerosis (TS). The dysplasia appears to result from a defect in cortical development, however, this disorder is heterogeneous, and FCD seizure therapy is non-specific and failure-prone. As a final recourse, patients may undergo multiple surgical resections to control seizures. Thus, there is a clinical need to characterize this disorder with respect to structural, molecular, and electrophysiological profiles, which will lead to development of animal models and pilot therapies that we will then apply to humans.

2015-06-01 | GSE62019 | GEO

Modeling Focal Cortical Dysplasia (FCD) using cortical organoids

Project description:Modeling Focal Cortical Dysplasia (FCD) using cortical organoids

| PRJNA730718 | ENA

Pilot Study Evaluating Everolimus Molecular Mechanisms in Tuberous Sclerosis Complex (TSC) and Focal Cortical Dysplasia (FCD)

Project description:Treatment resistant epilepsy in tuberous sclerosis complex (TSC) and some focal cortical dysplasias (FCDs) are associated with dysfunctional mammalian target of rapamycin (mTOR) signaling. This can upregulate cell growth and proliferation, with increased downstream ribosomal S6 protein phosphorylation (phospho-S6). mTOR inhibitors are used in TSC, the archetypal mTORopathy, to reduce tumor growth or seizure frequency. Preclinical studies in FCD support a potential role in suppressing seizures. This pilot study sought to evaluate the safety of the mTOR inhibitor everolimus in treatment-resistant (failure of > 2 anti-seizure medications) TSC and FCD patients undergoing surgical resection and to assess changes in mTOR signaling and molecular pathways.

2021-12-10 | MSV000088551 | MassIVE

Seizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis

Project description:Seizure-induced LIN28A disrupts pattern separation via aberrant hippocampal neurogenesis

| PRJNA1033558 | ENA

Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation (rTMS)_IN_VITRO

Project description:Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used in the study and treatment of neurological conditions including major depression, stroke, epilepsy, schizophrenia, multiple sclerosis, Parkinson’s, and Alzheimer’s disease, as well as other, non-neurological disorders. Among the effects of rTMS, low-frequency protocols (≤ 1Hz) are generally understood to result in cortical inhibition, whereas high-frequency protocols (≥ 3Hz) increase cortical excitability. However, the complex molecular basis of rTMS is largely unexplored. Using three complementary rat models, in vitro, ex vivo, and in vivo, we show complex patterns of hippocampal and neocortical transcriptional response to stimulation in glutamatergic and GABAergic signaling pathways, as well as multiple inflammatory pathways, among others. This broad-based molecular survey helps provide a foundation to tease out the complex molecular mechanisms of the effects of rTMS.

2023-05-30 | GSE230147 | GEO

Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation (rTMS)_IN_VIVO

2023-05-30 | GSE230149 | GEO

Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation (rTMS)_EX_VIVO

2023-05-30 | GSE230148 | GEO