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NURD dependent Reprogramming by Sall4-Jdp2-Esrrb-Glis1

ABSTRACT: NURD dependent Reprogramming by Sall4-Jdp2-Esrrb-Glis1

PROVIDER: PRJNA820848 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18507400_1.fastq.gz	Fastqsanger.gz
	SRR18507400_2.fastq.gz	Fastqsanger.gz
	SRR18507500_1.fastq.gz	Fastqsanger.gz
	SRR18507500_2.fastq.gz	Fastqsanger.gz
	SRR18507401_1.fastq.gz	Fastqsanger.gz

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Project description:Reprogramming somatic cells to pluripotency represents a paradigm for cell fate determination. A binary logic of closing and opening chromatin provides a simple way to understand iPSC reprogramming driven by both Yamanaka factors or chemicals. Here we apply this logic to the design a four factor combination, Jdp2, Glis1, Essrb and Sall4 (4F), that reprogram MEFs to chimera competent iPSCs efficiently. RNA- and ATAC-seq reveal differences between JGES and 7F induced pluripotency, 7IP and JGES IP, in transcriptomic and chromatin accessibility dynamics(CAD). Sall4 emerges as a dominant force that can close and open chromatin with the help of Jdp2 and Glis1 in resetting somatic chromatin to a pluripotent state. These results reveal a previously unknown path between somatic and pluripotent states, open a door for cell fate control.

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