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RNA sequencing of blood-resident Eµ-myc lymphoma cells from TpoTg and wild-type mice after Eµ-myc tumour transplant.

ABSTRACT: RNA sequencing of blood-resident Eµ-myc lymphoma cells from TpoTg and wild-type mice after Eµ-myc tumour transplant.

PROVIDER: PRJNA821490 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18537200.fastq.gz	Fastqsanger.gz
	SRR18537194.fastq.gz	Fastqsanger.gz
	SRR18537195.fastq.gz	Fastqsanger.gz
	SRR18537196.fastq.gz	Fastqsanger.gz
	SRR18537197.fastq.gz	Fastqsanger.gz

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RNA sequencing of blood-resident Eµ-myc lymphoma cells from TpoTg and wild-type mice after Eµ-myc tumour transplant.

Project description:RNA sequencing of blood-resident Eµ-myc lymphoma cells from TpoTg mice post tumour transplant revealed upregulated hallmark gene sets associated with inflammatory response, when compared to Eµ-myc tumour transplanted wild-type mice.

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Genome-wide analysis of gene expression in Eµ-Myc and Eµ-Myc Wrn Δhel/Δhel murine lymphomas

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Project description:Impact of CDK4-deficiency on Eµ-myc driven B-lymphoma By crossing mating CDK4 Knockout mice with Eµ-myc mice,We found CDK4-deficiency enhances the Eµ-myc induced B-lymphoma.We further to discover the molecular mechanism

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The effect on gene expression of Smchd1 deletion in pre-B cells from E17.5 Eµ-Myc embryos

Project description:Smchd1 appears to act as a tumour suppressor in the Eµ-Myc mouse B cell lymphoma model. We find a small number of gene expression differences at E17.5 in the pre-B cells, before phenotypic differences are observed. The microarrays compared Smchd1 null and Smchd1 wildtype E17.5 preB cell samples. All samples are on the C57BL/6 background and carry the Eµ-Myc transgene, and the Smchd1 null samples are additionally homozygous for a Smchd1 genetrap allele.

2012-09-30 | E-GEOD-40879 | biostudies-arrayexpress

The effect on gene expression of Smchd1 deletion in pre-B cells from E17.5 Eµ-Myc embryos

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Transgenic Eµ-myc mouse lymphoma array CGH data

Project description:We used array CGH data from Eµ-myc lymphomas to assess significant differences in DNA copy number variation between Cluster 1 and Cluster 2 lymphomas. When Eµ-myc mice had evidence of lymphoma and/or ill appearance, they were humanely sacrificed and dissected. Lymphoma tissue was obtained and flash frozen in liquid nitrogen. Later, lymphoma tissue was homogenized, and genomic DNA was extracted. Array CGH was performed on genomic DNA, with genomic DNA from normal background strain mice used as the reference.

2014-09-10 | E-GEOD-40759 | biostudies-arrayexpress

Transgenic Eµ-myc mouse lymphoma array CGH data

Project description:We used array CGH data from Eµ-myc lymphomas to assess significant differences in DNA copy number variation between Cluster 1 and Cluster 2 lymphomas.

2014-09-10 | GSE40759 | GEO

Transgenic Eµ-myc mouse lymphoma expression data for training dataset

Project description:We used gene expression data from Eµ-myc mouse lymphomas to perform unsupervised analyses that identified two lymphoma subgroups. We also used this data to develop a genomic signature to classify new lymphomas. When Eµ-myc mice had evidence of lymphoma and/or ill appearance, they were humanely sacrificed and dissected. Lymphoma tissue was obtained and flash frozen in liquid nitrogen. Later, lymphoma tissue was homogenized, and RNA was extracted. Gene expression microarrays were performed with the isolated RNA.

2014-09-10 | E-GEOD-40756 | biostudies-arrayexpress

Transgenic Eµ-myc mouse lymphoma expression data for test dataset [Mouse430_2]

Project description:We used gene expression data from Eµ-myc mouse lymphomas to test various genomic signatures and select lymphomas for further study When Eµ-myc mice had evidence of lymphoma and/or ill appearance, they were humanely sacrificed and dissected. Lymphoma tissue was obtained and flash frozen in liquid nitrogen. Lymphoma was dissociated into a single cell suspension, and cell pellets were frozen. Later, lymphoma tissue or cells were homogenized, and RNA was extracted. Gene expression microarrays were performed with the isolated RNA.

2014-09-10 | E-GEOD-40757 | biostudies-arrayexpress

Transgenic Eµ-myc mouse lymphoma expression data for test dataset [Mouse430A_2]

Project description:We used gene expression data from Eµ-myc mouse lymphomas to test various genomic signatures and select lymphomas for further study When Eµ-myc mice had evidence of lymphoma and/or ill appearance, they were humanely sacrificed and dissected. Lymphoma tissue was obtained and flash frozen in liquid nitrogen. Lymphoma and spleens were dissociated into single cell suspensions, and cell pellets were frozen. Later, lymphoma tissue or cells were homogenized, and RNA was extracted. Gene expression microarrays were performed with the isolated RNA.

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