Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparison of Methylation Episignatures in KMT2B and KMT2D-related human disorders

ABSTRACT: Comparison of Methylation Episignatures in KMT2B and KMT2D-related human disorders

PROVIDER: PRJNA821672 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18555100_1.fastq.gz	Fastqsanger.gz
	SRR18555100_2.fastq.gz	Fastqsanger.gz
	SRR18555101_1.fastq.gz	Fastqsanger.gz
	SRR18555101_2.fastq.gz	Fastqsanger.gz
	SRR18555102_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 98

Similar Datasets

Comparison of Methylation Episignatures in KMT2B and KMT2D-related human disorders

Project description:We compared the DNA methylation patterns in blood from individuals with two rare neurodevelopmental disorders (Childhood-onset dystonia (DYT-KMT2B) and Kabuki syndrome) and healthy control samples

2022-04-17 | GSE199836 | GEO

HBV-KMT2B integrated human induced pluripotent stem cells (KMT2B-Int iPSCs) vs heterozygous mutated KMT2B iPSCs (KMT2B-HT iPSCs) vs homozygous mutated KMT2B iPSCs (KMT2B-KO iPSCs) vs their original iPSCs (KMT2B-WT iPSCs)

Project description:Transcriptional profiling of all KMT2B-WT, HT, KO, Int iPSCs. KMT2B-HT, KO, and Int iPSCs were generated by gene editing using CRISPR/Cas9 and Cre recombinase technologies.

2023-11-15 | GSE217994 | GEO

CUT＆Tag analysis of HBV-KMT2B integrated HPCs and KMT2B heterozygous knockout HPCs

Project description:To investigate the global analysis of H3K4me3 of HBV-KMT2B integrated HPCs, CUT＆Tag analysis of HBV-KMT2B integrated HPCs and KMT2B heterozygous knockout HPCs was performed.

2025-01-01 | GSE244039 | GEO

Transcriptional profiling of all KMT2B-WT, HT, and Int HPCs. KMT2B-HT and Int iPSCs

Project description:HBV-KMT2B integrated human induced pluripotent stem cell-derived hepatic progenitor cells (KMT2B-Int HPCs) vs heterozygous mutated KMT2B human induced pluripotent stem cell-derived hepatic progenitor cells (KMT2B-HT HPCs) vs original human induced pluripotent stem cell-derived hepatic progenitor cells (KMT2B-WT HPCs) Transcriptional profiling of all KMT2B-WT, HT, and Int HPCs. KMT2B-HT and Int iPSCs were generated by gene editing using CRISPR/Cas9 and Cre recombinase technologies. iPSCs were differentiated into a hepatic lineage. On Day14 of hepatic differentiation, CD13 high and C133 high hepatic cells were sorted by fluorescence-activated cell sorter (FACS) on feeder mouse embryonic fibroblasts (MEFs). HPCs forms colony on MEFs and were stably cultured with maintaining their hepatic phenotype.

2025-01-01 | GSE217993 | GEO

Project description:HBV-KMT2B integrated human induced pluripotent stem cells (KMT2B-Int iPSCs) vs heterozygous mutated KMT2B iPSCs (KMT2B-HT iPSCs) vs homozygous mutated KMT2B iPSCs (KMT2B-KO iPSCs) vs their original iPSCs (KMT2B-WT iPSCs)

| PRJNA901875 | ENA

RNA-seq analysis of HeLa cells overexpressing histone methyltransferase KMT2B

Project description:KMT2B，a major H3K4 tri-methyltransferase, contributes to the development of various cancers. However, its role in cervical cancer is unclear. We found that KMT2B is upregulated in cervical cancer tissues, which is significantly associated with poor prognosis.To investigate the underlying mechanism of KMT2B in the progression of cervical cancer, we established stable KMT2B-overexpression HeLa cells.Then we compared the whole genome mRNA expression profile of KMT2B overexpression and control HeLa cells using RNA-seq.

2022-08-03 | GSE209928 | GEO

Long-read RNA-seq(Iso-seq) analysis of HBV-KMT2B integrated HPCs in which HBV genome is integrated into KMT2B region.

Project description:We identified full-length complementary DNA by long-read RNA-seq (Iso-seq) in HBV-KMT2B integrated HCC sample. To compare the data of HCC sapmle with HBV-KMT2B integrated HPCs, which reproduces the sequence of the HCC sample, we performed long-read RNA-seq in HBV-KMT2B integrated HPCs, as well.

2025-01-01 | GSE244522 | GEO

Effect of estradiol (E2) exposure and KMT2B knockdown on gene expression in MCF-7 cells

Project description:MCF-7 is an estrogen receptor-positive breast cancer cell line. This experiment is designed to study (1) the effect of estradiol (E2) exposure and (2) lysine methyltransferase 2B (KMT2B) knockdown in MCF-7 cells. Cells were grown for 72 hours prior to treatment with vehicle or 10 nM E2 for 4 and 24 hours. Additionally, to assess the effect of KMT2B knockdown, MCF-7 cells were transfected with KMT2B targeting siRNA or scrambled control siRNA in the absence or presence of E2. RNA were isolated using Trizol and hybridized to Affymetrix GeneChip Human Genome U133 Plus 2.0 array.

2017-01-30 | E-MTAB-4923 | biostudies-arrayexpress

Adolescent Drug Abuse, ADHD and Related Disorders

Project description:Adolescent Drug Abuse, ADHD and Related Disorders

| PRJNA498746 | ENA

Adolescent Drug Abuse, ADHD and Related Disorders

Project description:Adolescent Drug Abuse, ADHD and Related Disorders

| PRJNA498747 | ENA