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ABSTRACT: Kidney Transplant

PROVIDER: PRJNA821852 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18559600_1.fastq.gz	Fastqsanger.gz
	SRR18559600_2.fastq.gz	Fastqsanger.gz
	SRR18559700_1.fastq.gz	Fastqsanger.gz
	SRR18559700_2.fastq.gz	Fastqsanger.gz
	SRR18559601_1.fastq.gz	Fastqsanger.gz

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Kidney transplant recipients

Project description:Kidney transplant recipients

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Transcriptomic profiles of kidney allograft rejection: cell phenotype and origin, main biological pathways and interactions

Project description:To further explore the transcriptional changes in the kidney transplant biopsy at time of rejection, scRNAseq analysis was performed on 16 kidney transplant biopsy-derived cells using 10X Genomic technology.

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Identifying urinary RNA from prospective urine as non-invasive biomarkers for kidney transplant patients

Project description:To identify urinary RNA from prospective urine as non-invasive biomarkers for kidney transplant patients

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Molecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation

Project description:The aim of this study was to investigate correlations between early subclinical findings (10 and 90 day histology and gene expression data) and late outcomes (transplant glomerulopathy and graft loss) in positive crossmatch kidney transplants (+XMKTx). Our goal was threefold: first, to confirm that intragraft molecular changes at 12m post-transplant are associated with the observed histologic changes in SLK transplant recipients, compared with KTA transplant recipients; second, to ascertain whether specific molecular pathways/markers that are not accounted for by routine histology are differentially expressed in the kidney allografts of the SLK transplant recipients; and third, to determine whether a molecular signature that is uniquely associated with simultaneous liver transplantation can be identified in kidney allografts. Biopsy samples were from positive and negative crossmatch simultaneous liver-kidney transplant recipients (12 month protocol biopsies) were compared to control patient (positive and negative crossmatch) biopsies obtained at 12 months. This dataset is part of the TransQST collection.

2017-04-14 | E-GEOD-97780 | biostudies-arrayexpress

Identifying urinary RNA from biopsy associated urine as non-invasive biomarkers for kidney transplant patients

Project description:To identify urinary RNA from biopsy associated urine as non-invasive biomarkers for kidney transplant patients

2019-03-16 | GSE128348 | GEO

Molecular changes in kidney allografts after simultaneous liver-kidney compared with solitary kidney transplantation

2017-04-14 | GSE97780 | GEO

Molecular regulation of acute kidney injury (miRNA)

Project description:18 zero-hour and 18 selected post-transplant (Tx) biopsy samples from 18 kidney allografts (8 acute kidney injury (AKI), 10 PBx - protocol biopsies - controls) were analyzed by using the Affymetrix GeneChip® miRNA 3.0 Array.

2015-01-15 | GSE53771 | GEO

Trained immunity suppression determines kidney allograft survival [ChIP]

Project description:The innate immune system plays an essential role in regulating the immune responses to kidney transplantation, but the mechanisms through which innate immune cells influence long-term graft survival are unclear. The current study highlights the vital role of trained immunity in kidney allograft survival. Trained immunity describes the epigenetic and metabolic changes that innate immune cells undergo following an initial stimulus, allowing them have a stronger inflammatory response to subsequent stimuli. We stimulated healthy peripheral blood mononuclear cells with pretransplant and posttransplant serum of kidney transplant patients and immunosuppressive drugs in an in vitro trained immunity assay and measured tumor necrosis factor and interleukin 6 cytokine levels in the supernatant as a readout for trained immunity. We show that the serum of kidney transplant recipients collected 1 week after transplantation can suppress trained immunity. Importantly, we found that kidney transplant recipients whose serum most strongly suppressed trained immunity rarely experienced graft loss. This suppressive effect of posttransplant serum is likely mediated by previously unreported effects of immunosuppressive drugs. Our findings provide mechanistic insights into the role of innate immunity in kidney allograft survival, uncovering trained immunity as a potential therapeutic target for improving graft survival.

2024-11-04 | GSE280903 | GEO

Project description:Background: Hepatitis E Virus (HEV) is a new causative agent of chronic hepatitis in solid organ transplant recipients in Europe. Factors associated with the occurrence and persistence of chronic HEV infection remain largely unknown but chronic evolution seems to be the consequence of hostM-bM-^@M-^Ys immunological factors rather than of viral factors. Method: In a prospective case-control study, we have determined in whole blood of chronically HEV-infected kidney-transplant recipients the host response using microarray technology. Results: Chronically HEV-infected kidney-transplant recipients exhibited a specific transcriptional program, in which interferon effectors were prominent. The intensity of expression of each signatureM-bM-^@M-^Ys gene was significantly lower in patients who were subsequently cleared of HEV than in patients who were not. Furthermore, in patients who were cleared of HEV, a higher expression of these genes was associated with a longer delay until HEV clearance. Conclusions: The specific transcriptional program determined in chronically HEV-infected kidney-transplant recipients suggests an activation of type I interferon response. Intensity of interferon-stimulated genes expression could be useful to forecast the outcome of infection. High expression of interferon-stimulated genes could signify a dysregulation in the interferon response that might favour the persistence of the HEV infection. TrialM-bM-^@M-^Ys registration number: NCT01090232; RegistryM-bM-^@M-^Ys URL: http://clinicaltrials.gov/ct2/show/study/NCT01090232?term=kidney+transplant+recipients&cntry1=EU%3AFR&rank=2 Total RNA was extracted from whole-blood sample or monocytes of kidney-transplant patients with or without chronic hepatitis E (CHE) infection. Control patients were matched up with CHE patients for age, sex, time since kidney transplant and immunosuppressive treatment.

2013-01-29 | E-GEOD-36539 | biostudies-arrayexpress

Transcriptional trajectories of human kidney injury progression

Project description:RNAseq analysis on protocol biopsies obtained from 42 kidney transplant recipients at 4 time points after kidney transplantation.

2019-02-21 | GSE126805 | GEO

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