Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

ABSTRACT: RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

PROVIDER: PRJNA822087 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18579427_1.fastq.gz	Fastqsanger.gz
	SRR18579427_2.fastq.gz	Fastqsanger.gz
	SRR18579428_1.fastq.gz	Fastqsanger.gz
	SRR18579428_2.fastq.gz	Fastqsanger.gz
	SRR18579429_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 22

Similar Datasets

RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

Project description:RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

| PRJNA757134 | ENA

RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

Project description:The retinoblastoma tumor suppressor (RB1) plays a critical role in coordinating multiple pathways that impact on tumor initiation, disease progression, and therapeutic responses. Here we interrogated the effect of CDK4/6 inhibitor in combination with mTOR inhibtor. Also, we interrogtaed the efffect of AURK and WEE1 inhibition in ER+ breast cacner models While the RB-pathway has been purported to exhibit multiple mutually exclusive events, only RB1 is mutually exclusive with multiple genetic events that deregulate CDK4/6 activity. Using an isogenic ER+ breast cancer model with targeted RB1 deletion, we identified gene expression features that link CDK4/6 activity and RB-dependency (CDK4/6-RB integrated signature). We also investigated the role of RB on apoptotic pathway. Single copy loss on chromosome 13q encompassing the RB1 locus is prevalent in many cancers, and is associated with reduced expression of multiple genes on 13q including RB1, and inversely related to the CDK4/6-RB integrated signature supporting a genetic cause/effect relationship. To probe the broader implications on tumor biology, we investigated genes that are positively and inversely correlated with the CDK4/6-RB integrated signature. This approach defined tumor-specific pathways that could represent new therapeutic vulnerabilities associated with RB-pathway activity.

2021-08-31 | GSE182631 | GEO

RB-loss determines selective resistance and novel vulnerabilities in breast cancer modelsRB loss

2022-06-13 | GSE199919 | GEO

Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC

Project description:Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC

| PRJNA271815 | ENA

RB depletion is required for the continuous growth of tumors initiated by loss of RB

Project description:The retinoblastoma (RB) tumor suppressor is functionally inactivated in a wide range of human tumors where this inactivation promotes tumorigenesis in part by allowing uncontrolled proliferation. RB has been extensively studied, but its mechanisms of action in normal and cancer cells remain only partly understood. Here we describe a new mouse model to investigate the consequences of RB loss and its re-activation in vivo. In these mice, induction of shRNA molecules targeting RB for knock-down results in the development of phenotypes similar to RB knock-out mice, including the development of pituitary and thyroid tumors. Re-expression of RB leads to cell cycle arrest in cancer cells and repression of transcriptional programs driven by E2F activity. Thus, continuous RB loss is required for the maintenance of tumor phenotypes initiated by loss of RB, and this new mouse model will provide a new platform to investigate RB function in vivo.

2021-11-16 | GSE173749 | GEO

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

Project description:Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

| PRJNA887081 | ENA

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma [EPIC]

Project description:Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma [EPIC]

| PRJNA887097 | ENA

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma. [CRISPRseq]

Project description:Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma. [CRISPRseq]

| PRJNA887789 | ENA

Selective polyprotein processing determines norovirus sensitivity to Trim7

Project description:Selective polyprotein processing determines norovirus sensitivity to Trim7

| PRJEB47213 | ENA

Identification of the RB loss-induced transcriptome in prostate cancer [RNA]

Project description:The retinoblastoma protein (RB) is preferentially lost in the progression to castrate resistant prostate cancer (CRPC). However, the alterations associated with such loss have been scantly described. The current study aims to provide molecular mechanisms underlying Rb loss-driven CRPC phenotypes

2018-02-19 | GSE94863 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data