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Notch Signaling in the Thyroid is Essential for Adult Homeostasis (scRNAseq thyroid)

ABSTRACT: Notch Signaling in the Thyroid is Essential for Adult Homeostasis (scRNAseq thyroid)

PROVIDER: PRJNA823910 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18653185_1.fastq.gz	Fastqsanger.gz
	SRR18653185_2.fastq.gz	Fastqsanger.gz
	SRR18653186_1.fastq.gz	Fastqsanger.gz
	SRR18653186_2.fastq.gz	Fastqsanger.gz
	SRR18653187_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Notch Signaling in the Thyroid is Essential for Adult Homeostasis (scRNAseq thyroid)

Project description:Notch signaling between neighboring cells vitally contributes to specifying their identity and function, during development and in the adult. Here, we demonstrate that selective blockade of the Notch ligands JAG1 and JAG2 disrupts thermoregulation in adults by decreasing circulating thyroid hormones and thyroid function. By exploiting single-cell methods to carefully evaluate the thyroid, an understudied apex endocrine organ, we discovered unexpected thyrocyte heterogeneity, marked by three distinct thyrocyte subtypes with different Notch activation patterns.

2023-10-23 | GSE200267 | GEO

Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq thyroid)

Project description:Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq thyroid)

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Notch Signaling in the Thyroid is Essential for Adult Homeostasis.

Project description:Notch Signaling in the Thyroid is Essential for Adult Homeostasis.

| PRJNA823905 | ENA

Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq BAT)

Project description:Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq BAT)

| PRJNA823911 | ENA

Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq thyroid)

Project description:Notch signaling between neighboring cells vitally contributes to specifying their identity and function, during development and in the adult. Here, we demonstrate that selective blockade of the Notch ligands JAG1 and JAG2 disrupts thermoregulation in adults by decreasing circulating thyroid hormones and thyroid function. Sequencing data demonstrates that Notch inhibition decreases thyrocyte markers and mitochondrial genes.

2023-10-23 | GSE200265 | GEO

Notch Signaling in the Thyroid is Essential for Adult Homeostasis (RNAseq BAT)

Project description:Notch signaling between neighboring cells vitally contributes to specifying their identity and function, during development and in the adult. Here, we demonstrate that selective blockade of the Notch ligands JAG1 and JAG2 disrupts thermoregulation in adults by decreasing circulating thyroid hormones and thyroid function. Sequencing data in BAT demonstrates that Notch inhibition increases thermoregulation genes and this depends on thyroid hormones.

2023-10-23 | GSE200266 | GEO

scRNAseq of mouse corneal epithelium in homeostasis

Project description:scRNAseq of mouse corneal epithelium in homeostasis

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Thyroid hormone receptor a in skeletal muscle is essential for thyroid thermogenesis

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NOTCH dimerization contributes to maintenance of intestinal homeostasis

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Generation of thyroid follicular cell organoids from adult thyroid tissue [mouse]

Project description:The thyroid maintains systemic homeostasis by regulating serum thyroid hormone concentrations. Here we report the establishment of adult stem cell-derived three-dimensional (3D) organoids representing murine and human thyroid follicular cells (TFCs). The TFC organoids (TFCO) harbour the complete machinery of hormone production as visualised by the presence of colloid in the lumen and by the presence of essential transporters and enzymes in the polarised epithelial cells that surround a central lumen. Both the established murine as human thyroid organoids express canonical thyroid markers PAX8 and NKX2.1, while the thyroid hormone precursor thyroglobulin is expressed at comparable levels to tissue. Single cell RNA sequencing and transmission electron microscopy confirm that TFCOs phenocopy primary thyroid tissue. Thyroid hormones are readily detectable in conditioned medium of human TFCOs.

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