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Role of adipose tissue Na/K ATPase signaling in uremic cardiomyopathy

ABSTRACT: Role of adipose tissue Na/K ATPase signaling in uremic cardiomyopathy

PROVIDER: PRJNA824077 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18663903_1.fastq.gz	Fastqsanger.gz
	SRR18663903_2.fastq.gz	Fastqsanger.gz
	SRR18663904_1.fastq.gz	Fastqsanger.gz
	SRR18663904_2.fastq.gz	Fastqsanger.gz
	SRR18663905_1.fastq.gz	Fastqsanger.gz

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Role of adipose tissue Na/K ATPase signaling in uremic cardiomyopathy

Project description:The objective of the present study is to explore the role of human MSC derived adipocytes transduced with/without lenti adipo-NaKtide or lenti adipo-scrambled NaKtide in experimental uremic cardiomyopathy. We investigated the pathophysiological changes in recipient mice that underwent partial nephrectomy surgery, as a model of uremic cardiomyopathy, and implanted with NaKtide transfected human MSC derived adipocytes. We aimed to demonstrate that adipocyte specific NaKtide reprograms the adipocyte phenotype and transplantation of these metabolically healthy adipocytes in diseased condition exhibits improved systemic and cardiovascular function, through intra-organ crosstalk.

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Project description:Gene expression profiles in experimental uremic cardiomyopathy.

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Gene expression profiles in experimental uremic cardiomyopathy.

Project description:Purpose: To define differentially regulated pathways in heart tissue from mice with chornic kidney disease (CKD) compared to age-matched controls. Methods: CKD was induced in 5-week-old, male 129X1/SvJ mice (JAX) through five-sixths nephrectomy in a two-step surgery (n=5). Age-matched mice undergoing bilateral sham surgeries served as controls (n=5). Heart tissue was collected at 8 weeks of CKD for next generation sequencing. Results: Hearts from mice with uremic cardiomyopathy yielded over 1,000 differentially-expressed mRNA transcripts compared to hearts from age-matched, sham-operated mice. Ingenuity biofunctions analysis identified significant enrichment for genes involved in Tissue Morphology, Immune Cell Trafficking, Cardiovascular Development and Function, and Humoral Immune Response. We focused on Ingenuity canonical pathways involving inflammation and immune system function including pathways needed for a T-cell mediated response: leukocyte extravasation, antigen presentation, dendritic cell maturation, T cell co-stimulatory signaling, and T-helper cell differentiation. Conclusions: Left ventricles from mice with CKD display differential expression in a number of pathways suggesting inflammation and surprisingly involved genes involved in the adaptive immune system.

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