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Human 5-lipoxygenase regulates transcription by association to euchromatin

ABSTRACT: Human 5-lipoxygenase regulates transcription by association to euchromatin

PROVIDER: PRJNA824097 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18664200_1.fastq.gz	Fastqsanger.gz
	SRR18664200_2.fastq.gz	Fastqsanger.gz
	SRR18664201_1.fastq.gz	Fastqsanger.gz
	SRR18664201_2.fastq.gz	Fastqsanger.gz
	SRR18664202_1.fastq.gz	Fastqsanger.gz

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Project description:Human 5-lipoxygenase (5-LO) is the key enzyme of leukotriene biosynthesis, mostly expressed in leukocytes and thus a crucial component of the innate immune system. In this study, we show that 5-LO, beside its canonical function as a metabolizing enzyme, is also a regulator of gene expression in the monocytic cell line Mono Mac 6 (MM6). Using RNA-Seq, we identified 5-LO regulated genes which could be clustered to several biological functions, e.g. immune/defense response, cell adhesion, transcription and growth/developmental processes. Thereby, the majority of genes were upregulated by 5-LO KO. By conducting a ChIP-Seq analysis, we proved an association of 5-LO to DNA. In summary, we demonstrate an additional noncanonical function of 5-LO as a direct transcriptional regulator in MM6 cells that presumably regulates specific genes in dependence on histone acetylation.

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ACF1 regulates nucleosome spacing in Drosophila euchromatin

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