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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

ABSTRACT: Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

PROVIDER: PRJNA824195 | ENA |

REPOSITORIES: ENA

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Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): A Dynamic COVID-19 Community-Engaged Testing Strategy in Alabama (COVID COMET AL)

| PRJNA824194 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations(RADx-UP): Community Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

Project description:Rapid Acceleration of Diagnostics - Underserved Populations(RADx-UP): Community Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

| PRJNA772350 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations(RADx-UP): Community Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

Project description:Rapid Acceleration of Diagnostics - Underserved Populations(RADx-UP): Community Engaged Research on COVID-19 Testing Among Underserved and/or Vulnerable Populations

| PRJNA772351 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Research to Improve the COVID-19 Testing Cascade Among Underserved Populations in the US Caribbean Territories

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Research to Improve the COVID-19 Testing Cascade Among Underserved Populations in the US Caribbean Territories

| PRJNA789644 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Research to Improve the COVID-19 Testing Cascade Among Underserved Populations in the US Caribbean Territories

| PRJNA789647 | ENA

Alabama Ultisols

Project description:Alabama Ultisols Raw sequence reads

| PRJNA486327 | ENA

Improving Cancer Screening and Prevention During the COVID-19 Pandemic in Underserved Populations of Rhode Island

Project description:Lifespan Cancer Institute serves over 50% of cancer patients in the state. Rhode Island is known for strong medical care and high rates of cancer screening with mammography and colonoscopy. However, cancer screening has plummeted during the COVID-19 pandemic, in part to closing physician offices and stopping non-urgent medical procedures. In addition, anecdotal reports suggest the public remains concerned about returning to physician’s offices and risking possible exposure to COVID-19. As in the United States as a whole, COVID-19 has disproportionately impacted ethnic and minority individuals within underserved communities; and in Rhode Island, African Americans, Hispanics and undocumented individuals living in communities such as Central Falls, Pawtucket, Providence, East Providence and North Providence have had the highest rate of COVID-19. These communities are also impacted by healthcare disparities to access and affordability of healthcare, and as such, may be among the least likely to resume cancer screening. The Lifespan Cancer Institute will institute a project to address health disparities in cancer screening during the pandemic through the use of a targeted campaign involving social media. The goals will be to re-establish screening in the era of COVID-19 and ensure timeliness of care for those found to be at risk, or are positive for, cancer.

| 2354509 | ecrin-mdr-crc

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations (CATCH-UP)

Project description:Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations (CATCH-UP)

| PRJNA783112 | ENA

Rapid Acceleration of Diagnostics - Underserved Populations (RADx-UP): Community-engaged Approaches to Testing in Community and Healthcare Settings for Underserved Populations (CATCH-UP)

| PRJNA783113 | ENA

Molecular Disparities in Colorectal Cancers of White Americans, Alabama African Americans, and Oklahoma American Indians

Project description:In the US, the majority of cancer samples analyzed are from white people, leading to biases in racial and ethnic treatment outcomes. Colorectal cancer (CRC) incidence and mortality rates are high in Alabama African Americans (AAs) and Oklahoma American Indians (AIs). We hypothesized that differences between racial groups may partially explain these disparities. Thus, we compared transcriptomic profiles of CRCs of Alabama AAs, Oklahoma AIs, and white people from both states. Compared to CRCs of white people, CRCs of AAs showed (a) higher expression of cytokines and vesicle trafficking toward modulated antitumor-immune activity, and (b) lower expression of the ID1/BMP/SMAD axis, IL22RA1, APOBEC3, and Mucins; and AIs had (c) higher expression of PTGS2/COX2 (an NSAID target/pro-oncogenic inflammation) and splicing regulators, and (d) lower tumor suppressor activities (e.g., TOB2, PCGF2, BAP1). Therefore, targeting strategies designed for white CRC patients may be less effective for AAs/AIs. These findings illustrate needs to develop optimized interventions to overcome racial CRC disparities.

2023-08-23 | GSE237684 | GEO

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