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Effects of IsovalerylspiramycinⅠ(ISP-I) on gene expression profile of NSCLC cells

ABSTRACT: Effects of IsovalerylspiramycinⅠ(ISP-I) on gene expression profile of NSCLC cells

PROVIDER: PRJNA824342 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18672934_1.fastq.gz	Fastqsanger.gz
	SRR18672934_2.fastq.gz	Fastqsanger.gz
	SRR18672935_1.fastq.gz	Fastqsanger.gz
	SRR18672935_2.fastq.gz	Fastqsanger.gz
	SRR18672936_1.fastq.gz	Fastqsanger.gz

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Effects of IsovalerylspiramycinⅠ(ISP-I) on gene expression profile of NSCLC cells

Project description:To explore the possible mechanisms of ISP-I-induced NSCLC cell death, we performed RNA-seq comparisons of H460 and A549 after ISP-I treatment for 48h.

2022-05-31 | GSE200370 | GEO

RNA-sequencing of C.elegans isp-1 mutant and superoxide dismutase-isp-1 double mutants

Project description:isp-1;sod double mutants have decreased lifespan, increased resistance to oxidative stress and slow physiologic rates. We performed RNA sequencing to compare gene expression between isp-1 mutants and isp-1;sod-3 and isp-1;sod-5 double mutants

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RNA sequencing of PND55 mammary glands of mice fed 20% ISP, 1% ISP, 20% casein or Teklad 2018

Project description:Epidemiologic studies demonstrate that women from cultures that consume high levels of dietary soy have reduced breast cancer rates compared to women from cultures where soy consumption is typically much lower. The types of soy products consumed can also differ with Asian cultures consuming primarily minimally refined soy products while Western cultures often consume more highly refined soy products such as isolated soy protein (ISP). Our previous work showed that lifetime exposure to a diet containing 20% ISP promoted mammary tumor development in MTB-IGFIR transgenic mice. In this study, lifetime exposure to lower levels of ISP were evaluated (5% ISP and 1% ISP) to determine whether more moderate levels of ISP could protect against mammary tumorigenesis. A standard rodent diet, Teklad 2018 was also included in this study and Teklad 2018 contains a less refined form of soy, namely soybean meal. MTB-IGFIR mice fed ISP diets, independent of the concentration, displayed increased mammary tumor incidence and reduced tumor latency compared to MTB-IGFIR mice fed a 20% casein diet. Unexpectedly, MTB-IGFIR mice fed Teklad 2018 were completely protected against mammary tumor development. Although RNA sequencing of mammary tumors from ISP or casein fed mice did not identified gene expression patterns associated with the ISP diets, the ISP diets consistently promoted the expression of contractile related proteins in pubertal mammary glands. Therefore, lifetime exposure to ISP may alter gene expression in pubertal mammary glands rendering them more susceptible to transformation. Based on these findings women may want to avoid highly refined soy products such as ISP and switch to less refined forms of dietary soy until additional studies can be performed.

2020-07-15 | GSE122271 | GEO

RNA sequencing of mammary tumors induced in MTB-IGFIR transgenic mice fed 20% ISP, 1% ISP, or 20% Casein

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Initial Insights on the Proteomic Profile of Filipino Non-Small Cell Lung Carcinoma (NSCLC)

Project description:NSCLC remains to be the leading cause of cancer incidence and mortality in the Philippines. Early diagnosis, better understanding on the mechanisms of drug resistance, and proper treatment monitoring is necessary to lower the incidence and mortality rate of NSCLC. This study was able to provide initial insights on the proteomic profile of Filipino NSCLC by quantitative proteomic analysis and identification of aberrant expressions in the tumor tissue relative to the adjacent normal tissue specimen. A total of 4518 proteins were identified and from this, 1855 proteins were found to be significantly upregulated and downregulated. Functional and pathway analysis was done to the upregulated and downregulated proteins with at least 4-fold expression change. Pathway analysis revealed the possible activation of the upregulated protein, MUC1, which is a known oncogenic driver involved in the stimulation of pathways that promote angiogenesis in NSCLC tumor, and prevention of apoptosis. STAT1 and STAT3, also found upregulated in the tumor specimen, were known to have interactions with MUC1 which results to expression of proteins for cell proliferation. The analysis also suggests the stabilization of HIF which allows cell growth in the hypoxic tumor environment, and the activation of EIF signaling correlated with low survival rate of NSCLC patients. Our data demonstrate the rich proteomic information that can be obtained from comprehensive profiling of the NSCLC proteome and applications for better understanding of NSCLC tumorigenicity.

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Expression data of isp-1(qm150);ctb-1(qm189) mutant, exposed to klf-1 RNAi during development or adulthood

Project description:We showed that KLF-1 is needed for longevity of isp-1(qm150);ctb-1(qm189) mutant specifically in adulthood. We aimed to determine the expression changes that occur specifically upon adulthood klf-1 RNAi compared to developmental RNAi that did not affect the lifespan of isp-1(qm150);ctb-1(qm189) mutant.

2019-06-13 | GSE61771 | GEO

Streptomyces cinereoruber strain:NRRL ISP-5012 | isolate:NRRL ISP-5012

Project description:Streptomyces cinereoruber cinereoruber NRRL ISP-5012 genome sequencing

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Transcriptomic profile of the homeodomain protein CEH-23 under mitochondrial ETC stress in C. elegans

Project description:Transcriptomic profile of the homeodomain protein CEH-23 under mitochondrial ETC stress in C. elegans by comparing gene expression profile between isp-1(qm150) vs. ceh-23(ms23);isp-1(qm150) mutants

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