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Gene expression change after Enzalutamide treatment in MCF7 cells

ABSTRACT: Gene expression change after Enzalutamide treatment in MCF7 cells

PROVIDER: PRJNA824499 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18677476_1.fastq.gz	Fastqsanger.gz
	SRR18677476_2.fastq.gz	Fastqsanger.gz
	SRR18677477_1.fastq.gz	Fastqsanger.gz
	SRR18677477_2.fastq.gz	Fastqsanger.gz
	SRR18677478_1.fastq.gz	Fastqsanger.gz

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Gene expression change after Enzalutamide treatment in MCF7 cells

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Project description:Analysis of enzalutamide- and/or olaparib-responsive gene expression in prostate cancer cells. The hypothesis tested in the present study was that enzalutamide influences the expression of genes that are involved in important bioprocesses in prostate cance rcells, including DNA damage response genes and this effect may synergize with poly(ADP-ribose) polymerase inhibitor olaparib in cytotoxicity to prstate cancer cells. prostate cancer cells were pretreated with enzalutamide or vehicle control DMSO for 24 h, followed by treatment with enzalutamide, olaparib, enzalutamide+olaparib, or vehicle control DMSO for 48 h. Gene expression in enzalutamide+olaparib-treated cells was compared with taht in vehicle control- and single agent-treated cells.

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