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T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_feces]

ABSTRACT: T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_feces]

PROVIDER: PRJNA824504 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18677455_1.fastq.gz	Fastqsanger.gz
	SRR18677455_2.fastq.gz	Fastqsanger.gz
	SRR18677456_1.fastq.gz	Fastqsanger.gz
	SRR18677456_2.fastq.gz	Fastqsanger.gz
	SRR18677457_1.fastq.gz	Fastqsanger.gz

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T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity.

Project description:T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity.

| PRJNA824497 | ENA

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_cecum]

Project description:T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_cecum]

| PRJNA824505 | ENA

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [cohouse_feces]

Project description:T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [cohouse_feces]

| PRJNA824506 | ENA

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_feces]

Project description:The contribution of the environment and, in particular, the gut flora to multiple sclerosis (MS) etiology is well documented but not well understood. The aryl hydrocarbon receptor (AHR) binds numerous molecules present in the environment and is a therapeutic target for MS: however, its precise function in T lymphocytes, the orchestrators of MS, has not been described. Here, we show that CD4 specific Ahr knockout drives recovery in an animal model of MS driven by a decrease in T cell fitness. At the mechanistic level, we show that the absence of AHR changes the gut microenvironment composition to generate metabolites, such as bile salts and short chain fatty acids, that impact T cell viability. Our study demonstrates a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota while identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.

2022-04-10 | GSE200438 | GEO

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [sephouse_cecum]

2022-04-10 | GSE200437 | GEO

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity [cohouse_feces]

2022-04-10 | GSE200436 | GEO

T cell AHR activity tunes the Gut Microenvironment to Sustain Autoimmunity.

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-04-10 | GSE200440 | GEO

AhR interactome in early embryonic development

Project description:The transcriptional program of early embryonic development is tightly regulated by a set of well-defined transcription factors that suppress premature expression of differentiation genes and sustain the pluripotent identity. It is generally accepted that this program can be perturbed by environmental factors such as chemical pollutants, however the precise molecular mechanisms remain unknown. The Aryl Hydrocarbon Receptor (AHR) is a widely expressed nuclear receptor that senses environmental stimuli and modulates target gene expression. Here, we show that ectopic activation of AHR during early differentiation disrupts the differentiation program via the chromatin remodeling complex NuRD. The activated AHR/NuRD complex altered the expression of differentiation-specific genes that control the first two developmental decisions without affecting the pluripotency program. These findings identify a novel mechanism that allows environmental stimuli to disrupt embryonic development through AHR signaling.

2018-02-26 | PXD006089 | Pride

The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.

Project description:Multiple sclerosis (MS) is a T cell-driven autoimmune disease that attacks the myelin of the central nervous system (CNS) and currently has no cure. MS etiology is linked to both the gut flora and external environmental factors but this connection is not well understood. One immune system regulator responsive to nonpathogenic external stimuli is the aryl hydrocarbon receptor (AHR). The AHR, which binds diverse molecules present in the environment in barrier tissues, is a therapeutic target for MS. However, AHR's precise function in T lymphocytes, the orchestrators of MS, has not been described. Here, we show that in a mouse model of MS, T cell-specific Ahr knockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids. Our study demonstrates a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.

| S-EPMC9928083 | biostudies-literature

How the AHR became important in cancer: The role of chronically active AHR in cancer aggression

Project description:Sometimes biological research is an act of faith, a belief that untangling complex biologic interactions on a very basic level in-and-of itself eventually leads to larger and broader implications for human health. Indeed, sometimes focusing on the trees leads to a better view of the forest. This has been the case for the aryl hydrocarbon receptor (AHR). For decades, the AHR was studied for its role in environmental chemical toxicity i.e., as a quirk of nature and a mediator of unintended consequences of human pollution. During that period, it was not certain that the AHR had a “normal” physiological function. However, the ongoing accumulation of data from an ever-expanding variety of studies on cancer, cancer immunity, autoimmunity, organ development, and other areas bears witness to a staggering array of AHR-controlled normal and pathological activities. The objective of this review is to discuss how the AHR has gone from a likely contributor to genotoxic environmental carcinogen-induced cancer to a master regulator of malignant cell progression and cancer aggression. Particular focus was placed on the association between AHR activity and poor outcomes, feedback loops that control chronic AHR activity in cancer, and the role of chronically active AHR in driving cancer cell invasion, migration, cancer stem cell characteristics, and survival.

2023-12-11 | GSE163859 | GEO

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