Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

ABSTRACT: Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

PROVIDER: PRJNA824858 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18687460_1.fastq.gz	Fastqsanger.gz
	SRR18687460_2.fastq.gz	Fastqsanger.gz
	SRR18687461_1.fastq.gz	Fastqsanger.gz
	SRR18687461_2.fastq.gz	Fastqsanger.gz
	SRR18687462_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

Project description:To investigate the function of NCOR2-013 in T. marneffei-infected THP-1 macrophages, we established NCOR2-013 overexpression THP-1 macrphages. We then performed gene expression profiling analysis using data obtained from RNA-seq of T. marneffei-infected NCOR2-013 overexpression THP-1 macrophages and T. marneffei-infected control cells.

2023-09-25 | GSE200512 | GEO

RNA-seq of Talaromyces marneffei under mycelium and yeast conditions

Project description:Although many studies have focused on dimorphic switching, noncoding RNAs in Talaromyces marneffei have been neglected until now. rRNA depletion RNA-seq with or without RNase R treatment were performed in mycelium and yeast conditions of Talaromyces marneffei by to unveil the functions of circRNAs in dimorphic switching.

2023-05-08 | GSE231909 | GEO

Talaromyces marneffei

Project description:Talaromyces marneffei genome sequencing

| PRJNA522919 | ENA

Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing.

Project description:Talaromyces marneffei (T. marneffei) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei achieves immune escape through various strategies. However, the role of cellular alternative splicing (AS) in immune escape remains unclear. Here, we depict the AS landscape in macrophages upon T. marneffei infection via high-throughput RNA sequencing and detect a truncated protein of NCOR2 / SMRT, named NCOR2-013, which is significantly upregulated after T. marneffei infection. Mechanistic analysis indicates that NCOR2-013 forms a co-repression complex with TBL1XR1 / TBLR1 and HDAC3, thereby inhibiting JunB-mediated transcriptional activation of pro-inflammatory cytokines via the inhibition of histone acetylation. Furthermore, we identify TUT1 as the AS regulator that regulates NCOR2-013 production and promotes T. marneffei immune evasion. Collectively, these findings indicate that T. marneffei escapes macrophage killing through TUT1-mediated alternative splicing of NCOR2 / SMRT, providing insight into the molecular mechanisms of T. marneffei immune evasion and potential targets for talaromycosis therapy.

| S-EPMC10579421 | biostudies-literature

Talaromyces marneffei

Project description:Talaromyces marneffei Genome sequencing and assembly

| PRJNA825113 | ENA

Talaromyces marneffei

Project description:Talaromyces marneffei Genome sequencing and assembly

| PRJNA828342 | ENA

Talaromyces marneffei PM1

Project description:Talaromyces marneffei Transcriptome by RNA-seq

| PRJNA251718 | ENA

Talaromyces marneffei PM1

Project description:Talaromyces marneffei PM1 Hybrid Genome sequencing

| PRJNA251717 | ENA

Talaromyces marneffei PM1

Project description:Talaromyces marneffei PM1 Raw sequence reads

| PRJNA431116 | ENA

Excavation of biomarker candidates for the diagnosis of Talaromyces marneffei infection via genome-wide prediction and functional annotation of secreted proteins

Project description:Talaromyces marneffei is the third most common infectious pathogen in AIDS patients and leads to the highest death rate in Guangxi, China. The lack of reliable biomarkers is one of the major obstacles in current clinical diagnosis, which largely contributes to this high mortality. Here, we present a study that aimed at identifying diagnostic biomarker candidates through genome-wide prediction and functional annotation of Talaromyces marneffei secreted proteins. A total of 584 secreted proteins then emerged, including 382 classical and 202 non-classical ones. Among them, 87 newly obtained functional annotations in this study. The annotated proteins were further evaluated by combining RNA profiling and homology comparison. Three proteins were ultimately highlighted as biomarker candidates with robust expression and remarkable specificity. The predicted phosphoinositide phospholipase C and the galactomannoprotein were suggested playing an interactive immune game though metabolism of arachidonic acid. And therefore, they hold promises in developing new tools for clinical diagnosis of Talaromyces marneffei, possibly also serve as molecular targets of future therapy.

2024-06-20 | GSE266975 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data