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Interleukin-4 receptor signaling modulates neuronal network activity

ABSTRACT: Interleukin-4 receptor signaling modulates neuronal network activity

PROVIDER: PRJNA825260 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18701058.fastq.gz	Fastqsanger.gz
	SRR18701059.fastq.gz	Fastqsanger.gz
	SRR18701060.fastq.gz	Fastqsanger.gz
	SRR18701061.fastq.gz	Fastqsanger.gz
	SRR18701062.fastq.gz	Fastqsanger.gz

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Interleukin-4 receptor signaling modulates neuronal network activity [mouse]

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Interleukin-4 receptor signaling modulates neuronal network activity

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Interleukin-4 receptor signaling modulates neuronal network activity.

Project description:Evidence is emerging that immune responses not only play a part in the central nervous system (CNS) in diseases but may also be relevant for healthy conditions. We discovered a major role for the interleukin-4 (IL-4)/IL-4 receptor alpha (IL-4Rα) signaling pathway in synaptic processes, as indicated by transcriptome analysis in IL-4Rα-deficient mice and human neurons with/without IL-4 treatment. Moreover, IL-4Rα is expressed presynaptically, and locally available IL-4 regulates synaptic transmission. We found reduced synaptic vesicle pools, altered postsynaptic currents, and a higher excitatory drive in cortical networks of IL-4Rα-deficient neurons. Acute effects of IL-4 treatment on postsynaptic currents in wild-type neurons were mediated via PKCγ signaling release and led to increased inhibitory activity supporting the findings in IL-4Rα-deficient neurons. In fact, the deficiency of IL-4Rα resulted in increased network activity in vivo, accompanied by altered exploration and anxiety-related learning behavior; general learning and memory was unchanged. In conclusion, neuronal IL-4Rα and its presynaptic prevalence appear relevant for maintaining homeostasis of CNS synaptic function.

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