Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Fnip2 genetic variant in mouse tissues

ABSTRACT: Effect of Fnip2 genetic variant in mouse tissues

PROVIDER: PRJNA825543 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18716603.fastq.gz	Fastqsanger.gz
	SRR18716604.fastq.gz	Fastqsanger.gz
	SRR18716605.fastq.gz	Fastqsanger.gz
	SRR18716606.fastq.gz	Fastqsanger.gz
	SRR18716607.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 76

Similar Datasets

Effect of Fnip2 genetic variant in mouse tissues

Project description:We have modeled the Fnip2 rs2291007 genetic variant in the mouse genome. In this study we aimed to investigate the effect of this genetic variant in the transcriptome of two metabolically relevant tissues: liver and white adipose tissue (WAT)

2022-10-19 | GSE200620 | GEO

Effect of different hydrostatic pressures on mouse metatarsal and hip cartilage tissues

Project description:Effect of different hydrostatic pressures on mouse metatarsal and hip cartilage tissues

| PRJNA980133 | ENA

Effect of overexpression of A3B and RNA editing calling in mouse tissues

Project description:Effect of overexpression of A3B and RNA editing calling in mouse tissues

| PRJNA862149 | ENA

Effect of depletion of Rcrin on gene expression in mouse liver tissues

Project description:Effect of depletion of Rcrin on gene expression in mouse liver tissues

| PRJNA877114 | ENA

Effect of genetic DRYK1B KO

Project description:Effect of genetic DRYK1B KO

| PRJEB71501 | ENA

Effect of overexpression of A3B and RNA editing calling in mouse tissues [WES]

Project description:Effect of overexpression of A3B and RNA editing calling in mouse tissues [WES]

| PRJNA862153 | ENA

satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

Project description:satmut_utils: a simulation and variant calling package for multiplexed assays of variant effect

| PRJNA828159 | ENA

The dynamic effec of genetic variation on the in vivo ER stress transcriptional response in different tissues

Project description:The genetic regulation of gene expression varies greatly across tissue-type and individuals and can be strongly influenced by the environment. Many variants, under healthy control conditions, may be silent or even have the opposite effect under diseased stress conditions. This study uses an in vivo mouse model to investigate how the effect of genetic variation changes with cellular stress across different tissues. Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. This triggers the unfolded protein response (UPR), a large transcriptional response which attempts to restore homeostasis. This transcriptional response, despite being a conserved, basic cellular process, is highly variable across different genetic backgrounds, making it an ideal system to study the dynamic effects of genetic variation. In this study, we sought to better understand how genetic variation alters expression across tissues, in the presence and absence of ER stress. The use of different mouse strains and their F1s allow us to also identify context specific cis- and trans- regulatory variation underlying variable transcriptional responses. We found hundreds of genes that respond to ER stress in a tissue- and/or genotype-dependent manner. The majority of the regulatory effects we identified were acting in cis-, which in turn, contribute to the variable ER stress- and tissue-specific transcriptional response. This study demonstrates the need for incorporating environmental stressors across multiple different tissues in future studies to better elucidate the effect of any particular genetic factor in basic biological pathways, like the ER stress response.

2022-11-01 | GSE189419 | GEO

Effect of Genetic Variant in miR-196a-2 in MCF-7 cells

Project description:The impact of a SNP (rs11614913) in miR-196a-2 was examined by introducing expression vectors containing both the common and variant forms of the miRNA precursor.

2009-06-08 | GSE15576 | GEO

Effect of overexpression of A3B and RNA editing calling in mouse tissues [RNA-seq]

Project description:Effect of overexpression of A3B and RNA editing calling in mouse tissues [RNA-seq]

| PRJNA862154 | ENA