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Next-generation sequencing analysis of control mammary glands and ECD transgenic tumors

ABSTRACT: Next-generation sequencing analysis of control mammary glands and ECD transgenic tumors

PROVIDER: PRJNA826889 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18761353_1.fastq.gz	Fastqsanger.gz
	SRR18761353_2.fastq.gz	Fastqsanger.gz
	SRR18761354_1.fastq.gz	Fastqsanger.gz
	SRR18761354_2.fastq.gz	Fastqsanger.gz
	SRR18761355_1.fastq.gz	Fastqsanger.gz

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Next-generation sequencing analysis of control mammary glands and ECD transgenic tumors

Project description:Overexpression of ECD in mammary gland promotes mammary tumorigenesis. To determine the plausible mechanism of how ECD contributes the oncogenesis, we performed RNAseq analysis of three independent control mice mammary glands (6 months old) and four independent ECD transgenic mammary tumors. Out of these four tumors, T1a and T1b were adenosquamous carcinoma type, T3 was Spindle cell carcinoma type and T4 was papillary carcinoma. RNA was isolated from the respective samples and RNAseq was performed.

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Mammary Tissue: Wild type mammary glands vs IGF-IR induced mammary tumors vs IGF-IR independent tumors

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Expression data from mammary macrophages isolated from MMTV-iFGFR1 transgenic mice

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Expression data from mammary macrophages isolated from MMTV-iFGFR1 transgenic mice

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