Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparing the cerebellar transcriptome of Sacs KO versus WT mice

ABSTRACT: Comparing the cerebellar transcriptome of Sacs KO versus WT mice

PROVIDER: PRJNA827122 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR18769758.fastq.gz	Fastqsanger.gz
	SRR18769759.fastq.gz	Fastqsanger.gz
	SRR18769760.fastq.gz	Fastqsanger.gz
	SRR18769761.fastq.gz	Fastqsanger.gz
	SRR18769762.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Comparing the cerebellar transcriptome of Sacs KO versus WT mice

Project description:Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in SACS gene encoding sacsin. ARSACS patients and mouse models display early degeneration of cerebellum in agreement with high sacsin expression in this organ. We performed unbiased transcriptomic of cerebella from Sacs KO mice versus controls to dissect the mechanisms underlying cerebellar degeneration in ARSACS.

2023-08-08 | GSE200876 | GEO

TRAP from CA1 pyramidal neurons and cerebellar granule cells in Fmr1 KO and wildtype mice

Project description:TRAP (translating ribosome affinity purification) from CA1 pyramidal neurons and cerebellar granule cells in wildtype and Fmr1 KO littermate pairs. These data show a global downregulation of FMRP targets in Fmr1 KO mice in these cell types.

2020-01-07 | GSE127845 | GEO

MOG KO Tregs versus WT Tregs

Project description:Transcriptional comparison of WT Tregs versus MOG KO Tregs

2016-08-31 | GSE79124 | GEO

Comparing the difference in gene expression between TDAG51 WT vs TDAG51 KO, and TDAG51 KO Tg vs TDAG51 KO

Project description:Transcriptional profiling of postpartum day 0 mouse brain, comparing TDAG51 wild-type (WT) vs TDAG51 knockout (KO), and TDAG51 KO transgenic (Tg) vs TDAG51 KO.

2019-08-17 | GSE118675 | GEO

E47 KO versus WT HSCs

Project description:Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis.

2011-01-22 | GSE26788 | GEO

Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties

Project description:Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder (ASD), ADHD, learning difficulties and language delay. To provide a genetic model for the role of the cerebellum in ASD-related behaviors and study the role of ASTN2 in cerebellar circuit function, we generated global and PC-specific conditional Astn2 knockout (KO and cKO, respectively) mouse lines. Astn2 KO mice exhibited strong ASD-related behavioral phenotypes, including a marked decrease in separation-induced pup ultrasonic vocalization calls, hyperactivity, and repetitive behaviors, altered behavior in the three-chamber test, and impaired cerebellar-dependent eyeblink conditioning. Hyperactivity and repetitive behaviors were also prominent in Astn2 cKO animals but they did not show altered behavior in the three-chamber test. By Golgi staining, Astn2 KO PCs had region-specific changes in dendritic spine density and filopodia numbers. Proteomic analysis of Astn2 KO cerebellum revealed a marked upregulation of ASTN2 family member, ASTN1, a neuron-glial adhesion protein. Immunohistochemistry and electron microscopy demonstrated a significant increase in Bergmann glia volume in the molecular layer of Astn2 KO animals. Electrophysiological experiments indicated a reduced frequency of spontaneous excitatory postsynaptic currents (EPSCs), as well as increased amplitudes of both spontaneous EPSCs and inhibitory postsynaptic currents (IPSCs) in the Astn2 KO animals, suggesting that pre- and postsynaptic components of synaptic transmission were altered. Thus, ASTN2 regulates ASD-like behaviors and cerebellar circuit properties.

2024-07-30 | PXD052868 | Pride

Single cell RNAseq of Th17 and Th22 cells with Gpr65_WT versus KO

Project description:scRNAseq of in vitro polarized Th17 and Th22 cells (Gpr65_WT versus KO), to compare metabolism gene expression in Gpr65_WT versus KO.

2022-04-12 | GSE182767 | GEO

ON and OFF SACs identified by scRNA-seq

Project description:The goal of this experiment was to investigate the heterogeneity of SACs via scRNA-seq

2019-12-04 | GSE132507 | GEO

Epigenome analysis of NNMT KO versus WT cells

Project description:Epigenome analysis of NNMT KO versus WT cells

| PRJNA754404 | ENA

Comparative transcriptomic analysis of cerebellar astrocytes across developmental stages and brain regions

Project description:To profile gene expression differences in astrocytes in postnatal cerebellar astrocytes . Comparing cerebellar astrocyte transcriptomes at postnatal days 1, 7, 14, and 28 (P1, P7, P14, and P28),

2024-02-09 | GSE252519 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data