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Analysis of fucoidan-induced global transcriptional changes in bone marrow-derived dendritic cells (BMDCs) using RNA-Seq technology

ABSTRACT: Analysis of fucoidan-induced global transcriptional changes in bone marrow-derived dendritic cells (BMDCs) using RNA-Seq technology

PROVIDER: PRJNA827688 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR18788905_1.fastq.gz	Fastqsanger.gz
	SRR18788905_2.fastq.gz	Fastqsanger.gz
	SRR18788906_1.fastq.gz	Fastqsanger.gz
	SRR18788906_2.fastq.gz	Fastqsanger.gz
	SRR18788907_1.fastq.gz	Fastqsanger.gz

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Analysis of fucoidan-induced global transcriptional changes in bone marrow-derived dendritic cells (BMDCs) using RNA-Seq technology

Project description:To investigate the fucoidan-induced global change of signal transduction pathways, we prepared the bone marrow-derived dendritic cells (BMDCs) and treated them with fucoidan. We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different cells at one time point.

2022-04-21 | GSE200944 | GEO

RNA sequencing analysis of Bone Marrow-Derived Dendritic Cells (BMDCs) supplied with PBS or lysine

Project description:L-lysine (Lysine) is an indispensable amino acid that cannot be synthesized by the human body.We investigated whether lysine is involved in the remission of ulcerative colitis (UC) through dendritic cells.We performed RNA sequencing analysis in Bone Marrow-Derived Dendritic Cells (BMDCs) supplied with PBS or lysine to study the molecular mechanisms through which lysine regulates BMDCs gene expression.

2024-12-10 | GSE264507 | GEO

small RNAseq in donor BMDCs and BMDCs that received exosomes

Project description:small RNAseq was preformed on Wt bone marrow-derived dendritic cells (BMDC) and miR-155 and miR-146a double knockout (DKO) BMDCs that received Wt exosomes to investigate the differences in transferred miRNA Small RNA profiles were generated from Wt donor BMDCs and DKO BMDCs given Wt exosomes 3 replicates in each group

2016-07-03 | E-GEOD-67946 | biostudies-arrayexpress

small RNAseq in donor BMDCs and BMDCs that received exosomes

2016-01-01 | GSE67946 | GEO

Proteomic analysis identifies the potential effects of trichostatin A and bone marrow-derived dendritic cells on NIH3T3 cells under oxygen–glucose deprivation conditions

Project description:Fibroblasts usually mediate acute wound healing and long-term tissue remodeling with scarring in tissue injury. In myocardial infarction (MI), following a prolonged lack of oxygen supply, necrotized cardiomyocytes become replaced by secreted extracellular matrix proteins produced by fibroblasts. Dendritic cells (DCs) act as inflammatory cells and can migrate from the bone marrow to the infarct areas and infarct border areas to mediate collagen accumulation after MI, whereas trichostatin A (TSA) can regulate the apoptosis and proliferation of the fibroblasts and affect DCs functions under oxygen–glucose deprivation (OGD) conditions. In this study, we used proteomics to investigate the effects of TSA and bone marrow-derived dendritic cells (BMDCs) on NIH3T3 fibroblasts under OGD conditions. Results showed that the fatty acid degradation pathway was significantly upregulated in NIH3T3 cells under OGD conditions, and the fatty acid synthesis pathway was significantly downregulated in NIH3T3 cells treated with BMDCs conditioned media with TSA (BMDCs-CM[TSA]) under OGD conditions. Meanwhile, the BMDCs-CM(TSA) significantly decreased the levels of triglycerides and free fatty acids and mediated ten fatty acid metabolism-related proteins in the NIH3T3 cells under OGD conditions. Summarily, the proteomic analysis showed that TSA and BMDCs affect fatty acid metabolism in NIH3T3 cells under OGD conditions.

2024-05-21 | PXD021469 | Pride

Microarray of E. coli-infected bone marrow-derived dendritic cells

Project description:Dendritic cells (DCs) are critical mediators of host defense against bacteria. The goal of this microarray study was to understand the global transcriptional response of bone marrow-derived dendritic cells (BMDCs) upon exposure to live bacteria, to better understand how DCs orchestrate a host-protective immune response. We found that BMDCs upregulate a number of critical immune-related genes upon exposure to live E. coli. Most notably, the gene encoding hepcidin, a critical regulator of mammalian iron homeostasis, was significantly upregulated in BMDCs upon exposure to live bacteria.

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RNA sequencing of mouse bone marrow dendritic cells

Project description:Bulk mRNA from mouse bone marrow-derived dendritic cells (BMDCs) was sequenced. Samples were obtained from Wild Type (C57BL/6J) mice, or mice with GNAS knocked out specifically in CD11c +ve cells.

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Project description:Transcriptional profiling of Bone-Marrow derived mouse Dendritic Cells (bmDCs) infected with Ad-MyD88 vs. Ad-GFP or mock infected

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Effect of Leishmania infantum infection on the gene expression of murine bone marrow-derived dendritic cells

Project description:To investigate dendritic cells-Leishmania interaction, the transcriptional profile of bone marrow-derived dendritic cells (BMDCs) infected with Leishmania infantum or of cells exposed to chemically inactivated parasites was assessed

2022-08-03 | GSE204807 | GEO

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Project description:Gene expression analysis of the effect of MIDKINE (MDK) on bone marrow derived dendritic cells (BMDCs) cultured with Fms Related Receptor Tyrosine Kinase 3 Ligand (FLT3LG).

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